Aliases

• Hyaluronate-binding protein
• P98066
• TNF alpha-induced protein 6
• TNF-stimulated gene 6 protein
• TNFAIP6
• TSG-6
• TSG6
• Tumor necrosis factor-inducible gene 6 protein
• tumor necrosis factor, alpha-induced protein 6
• tumor necrosis factor-inducible gene 6 protein
• tumor necrosis factor-stimulated gene-6 protein

Description

From NCBI Gene: The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010]

Attributes

QA State

Curated

Type

Protein

HGNC Name

TNFAIP6