TRAF4
- Aliases
-
- CART1
- Cysteine-rich domain associated with RING and Traf domains protein 1
- MLN 62
- MLN62
- Metastatic lymph node gene 62 protein
- RING finger protein 83
- RNF83
- TNF receptor-associated factor 4
- TRAF4
- cysteine-rich domain associated with RING and Traf domains protein 1
- cysteine-rich domain associated with ring and TRAF domain
- malignant 62
- metastatic lymph node gene 62 protein
- tumor necrosis receptor-associated factor 4A
- Description
- TRAF4 is a member of the TNF receptor associated factor (TRAF) family. Members of the TRAF family are the major signal transducers for the TNF receptor (TNFR) superfamily and the interleukin-1 receptor/Toll-like receptor superfamily. TRAF4 is involved in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis.
Attributes
- QA State
- Curated
- Type
- Protein
- HGNC Name
- TRAF4
- Certifications
-
- None
- QA State for Breast
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Development and validation of sandwich ELISA microarrays with minimal assay interference.
- Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study.
- Expression and anti-apoptotic function of TRAF4 in human breast cancer MCF-7 cells.
- Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased.
- TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.