Abbreviated Name

PROS-RAPID

Lead Investigator

Sanda, Martin — Emory University

Coordinating Investigator

Zheng, Yingye — Fred Hutchinson Cancer Center

Involved Investigators

• — Johns Hopkins University Department of Urology
• Lokshin, Anna — University of Pittsburgh Cancer Institute
• Wagner, Andrew — Beth Israel Deaconess Medical Center
• Haab, Brian — Van Andel Research Institute
• Chan, Daniel — Johns Hopkins Medical Institutions
• Leach, Robin J — University of Texas Health Science Center at San Antonio
• Srivastava, Sudhir — National Cancer Institute
• Diamandis, Eleftherios P. — Mount Sinai Hospital
• Sanda, Martin — Emory University
• Zheng, Yingye — Fred Hutchinson Cancer Center

Abstract

Determine which markers move to validation using the prospectie prostate reference set samples.

Aims

Test candidate prostate markers at various labs using specimens collected and processed in a similar manner.

Analytic Method

N/A

Comments

Specimen Set Depleted

Outcome

hK2, hK4 and hK11 do not distinguish cases from controls. TSP-1 does not seem to distinguish cases from controls. %free PSA has some value: at 0-10% free PSA range for men whose PSA between 4-10 ng/ml, this cutoff point picks up near three folds cases as controls and has since moved on to validation.

Secure Outcome

No secure outcome available.

Publications

• No publications available at this time for this protocol.

Biomarkers

• KLK11
• KLK2
• KLK4
• ST14
• THBS1
• TMPRSS2:ERG

Data Collections

• No data collections available at this time for this protocol.

 Team Project

Start Date

Feb 1 2006

Estimated Finish Date

Feb 10 2007

Finish Date

Dec 31 2005

Protocol ID

127

Protocol Type

Reference Set

Fields of Research

• Other
• Proteomics

Collaborative Group

Prostate and Urologic Cancers Research Group

Cancer Types

• Malignant neoplasm of prostate