Abbreviated Name

LIVER REF

Lead Investigator

Parikh, Neehar — University of Michigan

Coordinating Investigator

Zheng, Yingye — Fred Hutchinson Cancer Center

Involved Investigators

• Schwartz, Myron — Mount Sinai Hospital
• Befeler, Alex — Saint Louis University
• Roberts, Lewis — Mayo Clinic
• Nguyen, Mindie — Stanford University
• Parikh, Neehar — University of Michigan
• Srivastava, Sudhir — National Cancer Institute
• Zheng, Yingye — Fred Hutchinson Cancer Center

Abstract

Utilize the remaining specimens collected under the DCP protocol to develop and validate markers for the early detection of HCC

Aims

Specific Aims Aim 1: To determine the sensitivity and specificity of des-gamma carboxyprothrombin (DCP) for the diagnosis of early hepatocellular carcinoma (HCC). Aim 2: To compare the accuracy of DCP and Alpha-fetoprotein (AFP) for the diagnosis of early HCC. Aim 3: To determine whether demographic or etiology of underlying liver disease alter the expression of DCP or AFP.

Analytic Method

N/A

Outcome

Utilize the remaining specimens collected under the DCP protocol to develop and validate markers for the early detection of HCC

Publications

• No publications available at this time for this protocol.

Biomarkers

• No biomarkers available at this time for this protocol.

Data Collections

• No data collections available at this time for this protocol.

 Team Project

Start Date

Feb 15 2008

Estimated Finish Date

Apr 15 2008

Finish Date

Sep 30 2010

Protocol ID

134

Protocol Type

Reference Set

Fields of Research

• Other

Collaborative Group

G.I. and Other Associated Cancers Research Group

Cancer Types

• Liver cell carcinoma