Abbreviated Name

Lung CARET

Lead Investigator

Hanash, Samir — The University of Texas MD Anderson Cancer Center

Coordinating Investigator

Zheng, Yingye — Fred Hutchinson Cancer Center

Involved Investigators

• Hanash, Samir — The University of Texas MD Anderson Cancer Center
• Srivastava, Sudhir — National Cancer Institute
• Zheng, Yingye — Fred Hutchinson Cancer Center

Abstract

see objectives

Aims

Aim 1: To validate the finding from pilot studies with CARET sera of autoantibodies to annexins I and II and PGP9.5 as potential biomarkers for lung cancers before the clinical diagnosis. Aim 2: To identify additional antigens and antibodies in sera from CARET participants, evaluating sensitivity and specificity by time before diagnosis, treatment arm, gender, and histologic type. Aim 3: To compare the findings for individual biomarker candidates and combinations of biomarker candidates in participants who were current smokers versus former smokers.

Analytic Method

Natural Array technique

Outcome

see objectives

Publications

• Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.

Biomarkers

• 14-3-3 theta
• Annexin 1 and SOX2
• ANXA1
• APEX1
• CYGB
• DAPK1
• EFEMP1
• Halling 4 marker LAVysion lung cancer probe set
• Hanash 3 marker panel for Lung Cancer
• LAMR1
• MPG
• OGG1
• PARK7
• PGP
• TCF21
• UCHL1

Data Collections

• Autoantibody Biomarkers

Start Date

Sep 5 2006

Estimated Finish Date

Sep 5 2007

Finish Date

Aug 7 2007

Protocol ID

138

Protocol Type

Validation

Fields of Research

• Proteomics

Collaborative Group

Lung and Upper Aerodigestive Cancers Research Group

Cancer Types

• Malignant neoplasm of bronchus and lung

Phased Status

2