Abbreviated Name

Breast Ref Set App: Li (2015)

Lead Investigator

Li, Christopher — Fred Hutchinson Cancer Center

Coordinating Investigator

Zheng, Yingye — Fred Hutchinson Cancer Center

Involved Investigators

• Li, Christopher — Fred Hutchinson Cancer Center
• Zheng, Yingye — Fred Hutchinson Cancer Center

Abstract

See objectives

Aims

No aims available.

Analytic Method

We propose to use our existing arrays for biomarker evaluation but to focus the evaluation on 9 candidates: KLK5,CRHBP, TFRC, ITGB4, RASGRF2, MUC5AC, FOLR3, YWHAB, CNOT7. These include the 8 marker panel described above that achieved 35% sensitivity at 5% specificity and the one additional marker from our A list that validated in our independent preclinical OS-WHI samples, CRHBP. The primary data analysis will focus on the combination of these 9 markers derived by logistic regression from the OS-WHI samples.

Outcome

See objectives

Publications

• No publications available at this time for this protocol.

Biomarkers

• CNOT7
• CRHBP
• FOLR3
• ITGB4
• KLK5
• Li 9 marker panel for breast cancer
• MUC5AC
• RASGRF2
• TFRC
• YWHAB

Data Collections

• No data collections available at this time for this protocol.

 Team Project

Start Date

Apr 12 2015

Estimated Finish Date

Oct 12 2015

Finish Date

Apr 15 2015

Protocol ID

403

Protocol Type

Reference Set

Fields of Research

• Proteomics

Collaborative Group

Breast and Gynecologic Cancers Research Group

Cancer Types

• Malignant neoplasm of breast