Singal, Amit

Open Protocols

Protocol Name Investigatory Role Biomarkers Data Collections
Clinical Validation Center for Hepatocellular Carcinoma Coordinating 0 0
HEDS Ref Set App: Hoshida (2024) Validation of etiology-specific "plug-in" PLSec assays Involved 0 0
HEDS Ref Set App: Singal (2024) Longitudinal changes in PLSec biomarker and HCC risk in the HEDS cohort Leading 0 0
HEDS Ref Set App: UTSW: Singal (2024) Leading 0 0
HEDS Reference Set Application: Amit Singal, UTSW (2025) Evaluation of GAAD and ASAP for early-stage HCC detection Leading 0 0
National Liver Cancer Screening Trial (TRACER) Leading 0 0

Closed Protocols

Protocol Name Investigatory Role Biomarkers Data Collections
HEDS Ref Set - UTSW Data Only Leading 0 0
HEDS Reference Set Application: Amit Singal, UTSW (2021) Prognostic Liver Secretome signature Validation Leading 0 0
Hepatocellular carcinoma Early Detection Strategy study Involved 1 0
Liver Rapid Reference Set Mehta-Singal (2022) Involved 0 0

Publications

Publication NamePubMed IDJournal
A Biomarker Panel Based upon AFP, Fucosylated Kininogen and PEG-Precipitated IgG Is Highly Accurate for the Early Detection Hepatocellular Carcinoma in Patients with Cirrhosis in Phase II and Phase III Biomarker Evaluation. 36497452 Cancers (Basel)
AI-based phenotyping of hepatic fiber morphology to inform molecular alterations in metabolic dysfunction-associated steatotic liver disease. 40262132 Hepatology
Association of Epigenetic Aging Biomarkers With Risk of MASLD-Related HCC. 41316838 Liver Int
Blood-Based Biomarkers for HCC Surveillance: Ready for the Center Stage? 37795908 Am J Gastroenterol
Evaluation of LI-RADS 3 and 4 Lesions. 39622280 Gastroenterology
Extracellular vesicle digital scoring assay for assessment of treatment responses in hepatocellular carcinoma patients. 40307890 J Exp Clin Cancer Res
GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatocellular carcinoma. 16137783 J Hepatol
Incidental Findings During Hepatocellular Carcinoma Surveillance in Patients With Cirrhosis. 40349897 Clin Gastroenterol Hepatol
Increased levels of galactose-deficient anti-Gal immunoglobulin G in the sera of hepatitis C virus-infected individuals with fibrosis and cirrhosis. 18045939 J Virol
Integrative Analysis of Fucosylated Tetra Glycoforms in Hepatocellular Carcinoma: A NanoLC-PRM-MS/MS and Machine Learning Approach. 41212027 J Proteome Res
Leveraging multi-cancer blood tests to improve diagnostic efficiency for patients with nonspecific signs and symptoms. 39193702 Future Oncol
Longitudinal changes in fibrosis markers are associated with risk of cirrhosis and hepatocellular carcinoma in non-alcoholic fatty liver disease. 36402450 J Hepatol
Multicenter evaluation of abbreviated MRI and ultrasound for detecting early-stage hepatocellular carcinoma. 40321196 JHEP Rep
Patient-Perceived Risk of Hepatocellular Carcinoma and Net Benefit of Surveillance: A Multicenter Survey Study. 40267274 Am J Gastroenterol
Phase 3 Validation of PAaM for Hepatocellular Carcinoma Risk Stratification in Cirrhosis. 39521255 Gastroenterology
Risk-stratified surveillance for hepatocellular carcinoma. 41921193 Hepatol Commun
SELDI-TOF MS profiling of serum for detection of the progression of chronic hepatitis C to hepatocellular carcinoma. 15726646 Hepatology
Serum levels of total bile acids are associated with an increased risk of HCC in patients with cirrhosis. 39652379 Hepatol Commun
Spatial omics-based machine learning algorithms for the early detection of hepatocellular carcinoma. 39627514 Commun Med (Lond)
Survival following liver transplantation for hepatocellular carcinoma after implementation of MMaT-3 policy. 37129867 Liver Transpl
Temporal Changes in Risk Factors of Hepatocellular Carcinoma in a Prospective Cirrhosis Cohort. 39694208 Clin Gastroenterol Hepatol
The Future Role of Abdominal US in Hepatocellular Carcinoma Surveillance. 38742973 Radiology
Very Early-Stage Detection Is Associated With Improved Survival in Patients With Unifocal Hepatocellular Carcinoma. 41173809 Aliment Pharmacol Ther

Interests

Hepatocellular carcinoma
My research focuses on risk stratification and early detection of liver cancer in patients with cirrhosis, including evaluation of emerging blood- and imaging-based screening strategies.

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Photograph of Singal, Amit
Site
UT Southwestern Medical Center
Degree(s)
M.D.
Email
amit.singal@utsouthwestern.edu
Person ID
4686
EDRN Title
EDRN Principal Investigator
Note
To update contact information, please visit the Data Management and Coordinating Center .