Open Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
Indeterminate pulmonary nodule biomarker clinical utility trial	Leading	0	0
LTP2 Analysis-Imaging-Herman Pittsburgh (2023)	Leading	0	0
Validation of Molecular Biomarkers for the Early Detection of Lung Cancer in the setting of Indeterminate Pulmonary Nodules (Lung Team Project #2)	Involved	15	0

Closed Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
LTP2 Results Analysis-Herman-UPittsburgh 2024	Leading	0	0

Publications

Publication Name	PubMed ID	Journal
A sample-to-answer droplet magnetofluidic assay platform for quantitative methylation-specific PCR.	29594810	Biomed Microdevices
Detection of Promoter DNA Methylation in Urine and Plasma Aids the Detection of Non-Small Cell Lung Cancer.	32430478	Clin Cancer Res
DNA-methylation for the detection and distinction of 19 human malignancies.	33666134	Epigenetics
Facile profiling of molecular heterogeneity by microfluidic digital melt.	30263958	Sci Adv
Highly Efficient Real-Time Droplet Analysis Platform for High-Throughput Interrogation of DNA Sequences by Melt.	31356737	Anal Chem
Leveraging locus-specific epigenetic heterogeneity to improve the performance of blood-based DNA methylation biomarkers.	33081832	Clin Epigenetics
Ligation-Enabled Fluorescence-Coding PCR for High-Dimensional Fluorescence-Based Nucleic Acid Detection.	33427441	Anal Chem
Multilayer microfluidic array for highly efficient sample loading and digital melt analysis of DNA methylation.	30623957	Lab Chip
Noninvasive Diagnostics for Early Detection of Lung Cancer: Challenges and Potential with a Focus on Changes in DNA Methylation.	33148791	Cancer Epidemiol Biomarkers Prev
Postoperative Lymph Is a Proximal Source of ctDNA for Detection of Recurrence in HPV-Independent Head and Neck Cancer.	41182409	Clin Cancer Res
Ultrasensitive DNA hypermethylation detection using plasma for early detection of NSCLC: a study in Chinese patients with very small nodules.	32138766	Clin Epigenetics
Utilizing MiSeq Sequencing to Detect Circulating microRNAs in Plasma for Improved Lung Cancer Diagnosis.	37373422	Int J Mol Sci

Interests

Use of DNA methylation detection for diagnosis, early detection, and MRD

Use of DNA methylation detection for diagnosis, early detection, and MRD

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Site

University of Pittsburgh School of Medicine

Degree(s)

M.D.

Email

hermanj3@upmc.edu

Person ID

3730

Note

To update contact information, please visit the Data Management and Coordinating Center .