KLK11

Aliases
  • Hippostasin
  • KLK11
  • Kallikrein-11
  • PRSS20
  • Serine protease 20
  • TLSP
  • hk11
  • kallikrein 11
  • kallikrein-related peptidase 11
Description
The glandular kallikreins are a distinct group of serine proteases with molecular masses of 25,000 to 40,000. Kallikreins are a subgroup of serine proteases having diverse physiological functions. hk11 is a possible multifunctional protease which efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Several human kallikrein genes have been isolated. Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate.
Attributes
QA State
Accepted
Type
Protein
HGNC Name
KLK11
Certifications
  • None
QA State for Breast
Under Review

 Non-Public Biomarker

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.

Certifications
  • None
QA State for Lung
Under Review

 Non-Public Biomarker

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.

Certifications
  • None
QA State for Prostate
Accepted
Organ-Specific Notes

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene, hk11 (KLK11) is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms which are differentially expressed.

Performance Comment

hK2, hK4 and hK11 do not distinguish cases from controls in these populations.

Supporting Study Data
Prostate Rapid Pre-Validation Set
Study phase on the prostate: 2

Determine which markers move to validation using the prospectie prostate reference set samples.

View Protocol
Decision rule: No clinically useful decision rule found.
Prostate Rapid Reference Set Application: Eleftherios Diamandis - Mt Sinai (2006)
Study phase on the prostate: 2

No description of this protocol is available.

View Protocol
Decision rule: No clinically useful decision rule found.
Prostate-Specific Protocols
  • No organ-level protocols specified for prostate.
Prostate-Specific Publications
  • No organ-level publications were listed for prostate.
Prostate-Specific Resources
  • No organ-level resources were given for prostate.
  • No science data collections were specified for this biomarker.