THBS1

Aliases
  • THBS
  • THBS-1
  • THBS1
  • TSP
  • TSP-1
  • TSP1
  • Thrombospondin (THBS)
  • Thrombospondin-1
  • thrombospondin-1p180
Description
TSP is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. TSP can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. It has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.
Attributes
QA State
Accepted
Type
Protein
HGNC Name
THBS1
Certifications
  • None
QA State for Breast
Under Review

 Non-Public Biomarker

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.

Certifications
  • None
QA State for Pancreas
Under Review

 Non-Public Biomarker

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.

Certifications
  • None
QA State for Prostate
Accepted
Organ-Specific Notes

Blood protein markers that provide more accurate or earlier diagnosis of prostate cancer should have a positive impact on prostate cancer treatment and management. Experimental evidence shows that thrombospondin-1 levels are elevated in patients with benign prostatic disease and repressed in patients with prostate cancer. Thrombospondin-1 levels do not correlate with prostate-specific antigen (PSA) levels and differentiate benign from malignant disease with 79% sensitivity and 81% specificity. The measurement of thrombospondin-1 could be used to assist the decision to obtain a biopsy in men with suspected prostate cancer, which could lead to a reduction in the number of unnecessary prostatic biopsies.

Performance Comment

TSP did not, for the populations tested in these experiments, show strong pre-diagnostic performance. This biomarker has not moved on to Phase 3 study.

Supporting Study Data
Prostate Rapid Pre-Validation Set
Study phase on the prostate: 2

Determine which markers move to validation using the prospectie prostate reference set samples.

View Protocol
Decision rule: No clinically useful decision rule found.
Prostate Rapid Reference Set Application: Brian Haab - Van Andel (2006)
Study phase on the prostate: 2

No description of this protocol is available.

View Protocol
Decision rule: No clinically useful decision rule found.
Prostate Rapid Reference Set Application: Eleftherios Diamandis - Mt Sinai (2006)
Study phase on the prostate: 2

No description of this protocol is available.

View Protocol
Decision rule: No decision rule specified.
Prostate-Specific Protocols
  • No organ-level protocols specified for prostate.
Prostate-Specific Publications
  • No organ-level publications were listed for prostate.
Prostate-Specific Resources
  • No organ-level resources were given for prostate.
  • No science data collections were specified for this biomarker.