Aliases

• RPS27A
• UBA52
• UBB
• UBC
• Ubiquitin

Description

The ubiquitin protein was named due to its ubiquitous presence in the human body. This small protein, comprised of 76 amino acids, is coded for by a family of genes whose translation products are fusion proteins. The four genes that are known to code for ubiquitin are UBB, UBC, UBA52, and RPS27A. Ubiquitin molecules are often bound to other proteins as a marker for degradation. From NCBI Gene: Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.[provided by RefSeq, Sep 2008]

Attributes

QA State

Curated

Type

Protein

HGNC Name