UCHL1
- Aliases
-
- Neuron cytoplasmic protein 9.5
- PARK5
- PGP 9.5
- PGP9.5
- PGP95
- UCH-L1
- UCHL1
- Ubiquitin thioesterase L1
- Uch-L1
- ubiquitin C-terminal hydrolase
- ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
- ubiquitin carboxyl-terminal hydrolase isozyme L1
- Description
- PGP9.5, also called Ubiquitin-protein hydrolase (UCHL1), is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Oxidation of Met-1, Met-6, Met-12, Met-124 and Met-179 to methionine sulfoxide, and oxidation of Cys-220 to cysteine sulfonic acid have been observed in brains from Alzheimer disease (AD) and Parkinson disease (PD) patients. PGP9.5 has been proposed as a marker with a potential role in carcinogenesis.
Attributes
- QA State
- Accepted
- Type
- Protein
- HGNC Name
- UCHL1
- Certifications
-
- None
- QA State for Lung
- Under Review
Non-Public Biomarker
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- Autoantibody profiling for cancer detection.
- Determination of metastasis-associated proteins in non-small cell lung cancer by comparative proteomic analysis.
- Integral protein microarrays for the identification of lung cancer antigens in sera that induce a humoral immune response.
- Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
- Proteomics-based identification of protein gene product 9.5 as a tumor antigen that induces a humoral immune response in lung cancer.
- The role of PGP9.5 as a tumor suppressor gene in human cancer.
- Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis.