Abbreviated Name

Breast Ref Set App: Tuszynski (2012)

Lead Investigator

Tuszynski, George — Temple University

Coordinating Investigator

Zheng, Yingye — Fred Hutchinson Cancer Center

Involved Investigators

• Srivastava, Sudhir — National Cancer Institute
• Tuszynski, George — Temple University
• Zheng, Yingye — Fred Hutchinson Cancer Center

Abstract

No abstract availalbe.

Aims

We are addressing the question of whether G-protein coupled receptor-associated sorting protein 1 (GASP-1) initially discovered in the serum of breast cancer patients can be used as a serum biomarker for the early detection, diagnosis or prognosis of breast cancer.

Analytic Method

We will use logistic regression to test if GASP-1 is associated with case-control status after adjustment for age and body mass index. As described in the breast cancer reference set description document, with sample size of 30 cases and 30 controls the study has excellent power for a positive result if the marker is associated with breast cancer (OR=5 for a dichotomized version of the marker). An age-adjusted ROC curve and AUC for the GASP-1 marker will be calculated along with bootstrap confidence limits

Publications

• No publications available at this time for this protocol.

Biomarkers

• CA125
• CA15-3
• CA19-9
• CEACAM5
• GPRASP1

Data Collections

• No data collections available at this time for this protocol.

Finish Date

Dec 4 2018

Protocol ID

367

Protocol Type

Reference Set

Fields of Research

• Proteomics

Collaborative Group

Breast and Gynecologic Cancers Research Group

Cancer Types

• Malignant neoplasm of breast