Development of a magneto-nanosensor (MNS) array for prostate cancer biomarkers

Abbreviated Name
MNS_validation
Lead Investigator
Gambhir, Sam — Stanford University
Coordinating Investigator
No coordinating investigator
Involved Investigators

Abstract

No abstract availalbe.

Aims

Specific Aim 1: To adapt the magneto-nanosensor array platform to the multiplex measurement of prostate cancer biomarkers for detection and progression. To accomplish this we will functionalize our magneto-nanosensor with capture antibodies for an extended panel of leading biomarker candidates for prostate cancer detection and prognostication rigorously selected from the literature. Initial experiments will be performed to evaluate the performance of the array to detect spiked samples with known quantities of biomarkers, to establish calibration curves, determine the lower limits of detection, and assess reproducibility. Once the array has been completed we will progress to evaluate it using the clinical discovery sample set described in Aim #2. Specific Aim 2: To evaluate the accuracy of the prostate cancer magneto-nanosensor array to classify clinical cancer and control specimens from the Stanford serum bank. For this aim we will test the ability of the array to accurately classify archival serum samples drawn from prostate cancer patients before and after radical prostatectomy, and from patients with positive and negative biopsies. These sera were collected by the PSA analysis laboratory in the Urology Department at the Stanford University Medical Center.

Analytic Method

No analytic method available.

Publications

  • No publications available at this time for this protocol.

Biomarkers

  • No biomarkers available at this time for this protocol.

Data Collections

  • No data collections available at this time for this protocol.
 Team Project
Start Date
Sep 1 2012
Estimated Finish Date
Jun 30 2015
Protocol ID
370
Protocol Type
Collaboration
Fields of Research
  • Nanotechnology
  • Proteomics
Collaborative Group
G.I. and Other Associated Cancers Research Group
Cancer Types
  • Malignant neoplasm of prostate
Phased Status
2

Associated Forms