Abbreviated Name

Biomarker Detection Using NAPPA Tumor Antigen Arrays

Lead Investigator

LaBaer, Joshua — Arizona State University

Coordinating Investigator

Anderson, Karen — Arizona State University

Involved Investigators

• Anderson, Karen — Arizona State University
• Marks, Jeffrey — Duke University Medical Center
• LaBaer, Joshua — Arizona State University
• Engstrom, Paul — Fox Chase Cancer Center

Abstract

No abstract availalbe.

Aims

Aim 1: Optimize NAPPA as a cancer autoantibody detection platform Aim 2: Identify tumor antigen-specific antibodies in a test set of early-stage breast cancer patient sera Aim 3: Validate the detection of tumor antigen-specific antibodies in early-stage breast cancer patient sera.

Analytic Method

Protein microarray and ELISA assays

Outcome

The overall goal of this project is to identify autoantibody biomarkers in sera that can be readily used for the early detection of cancers

Publications

• Protein microarray signature of autoantibody biomarkers for the early detection of breast cancer.

Biomarkers

• ALG10
• ATF3
• ATP6AP1
• BDNF
• BMX
• C15orf48
• CSNK1E
• CTBP1
• DBT
• EIF3E
• FRS3
• GPANK1
• GPR157
• HOXD1
• MYOZ2
• PDCD6IP
• RAB5A
• RAC3
• SELL
• SERPINH1
• SF3A1
• SLC33A1
• SOX2
• TFCP2
• TRIM32
• UBAP1
• ZMYM6
• ZNF510

Data Collections

• No data collections available at this time for this protocol.

Start Date

Aug 1 2005

Estimated Finish Date

Aug 1 2010

Finish Date

Jul 2 2010

Protocol ID

401

Protocol Type

Collaboration

Fields of Research

• Proteomics

Collaborative Group

Breast and Gynecologic Cancers Research Group

Cancer Types

• Malignant neoplasm of breast

Phased Status

1