LaBaer, Joshua

Open Protocols

Protocol Name Investigatory Role Biomarkers Data Collections
Indeterminate pulmonary nodule biomarker clinical utility trial Involved 0 0
LTP2 Results Analysis-LaBaer (2024) Leading 0 0
Novel approaches to study immune responses to post translational modifications for cancer detection Leading 0 0

Closed Protocols

Protocol Name Investigatory Role Biomarkers Data Collections
Biomarker Detection Using NAPPA Tumor Antigen Arrays Leading 28 0
Breast Reference Set Application: Karen Anderson-ASU (2014) Involved 1 0
Triple Negative Breast Cancer Team Project Involved 147 0

Publications

Publication NamePubMed IDJournal
<i>Helicobacter pylori</i> Immunoproteomic Profiles in Gastric Cancer. 33108201
A Contra Capture Protein Array Platform for Studying Post-translationally Modified (PTM) Auto-antigenomes. 27141097
A versatile protein microarray platform enabling antibody profiling against denatured proteins. 23027520
Advances in cell-free protein array methods. 29214870
Advances in plasma proteomics: Moving from technology to precision medicine. 36377435
Advancing translational research with next-generation protein microarrays. 26749402
Anti-Epstein-Barr virus (EBV) antibodies in EBV-associated gastric carcinoma. 41928280 Infect Agent Cancer
Antiviral antibody profiling by high-density protein arrays. 25758251
Applications of protein microarrays for biomarker discovery. 21136793 Proteomics Clin Appl
Autoantibodies in Early Detection of Breast Cancer. 32994341
Autoantibodies, antigen-autoantibody complexes and antigens complement CA125 for early detection of ovarian cancer. 38195887
Autoantibody biomarkers for the detection of serous ovarian cancer. 28427776
Autoantibody profiles as biomarkers of breast cancer. 20938085 Cancer Biomark
Autoantibody signature for the serologic detection of ovarian cancer. 25365139
Automatic Identification and Quantification of Extra-Well Fluorescence in Microarray Images. 28938071
Beyond Sequencing: Prioritizing and Delivering Neoantigens for Cancer Vaccines. 34914074 Methods Mol Biol
Biologic characteristics of premalignant breast disease. 22112476 Cancer Biomark
Biomarker discovery for heterogeneous diseases. 23462916 Cancer Epidemiol Biomarkers Prev
Circulating tumor HPV DNA, antibodies to HPV16 early proteins, and oral HPV16 DNA as biomarkers for HPV-related oropharyngeal cancer screening. 40116780 Cancer Biomark
Comparative Microbiomics Analysis of Antimicrobial Antibody Response between Patients with Lung Cancer and Control Subjects with Benign Pulmonary Nodules. 36066883
Comparative Study of Autoantibody Responses between Lung Adenocarcinoma and Benign Pulmonary Nodules. 26896032 J Thorac Oncol
Development of a multiplexed lateral flow assay for the serologic detection of HPV-associated head and neck cancer. 40179433 Cancer Biomark
Diagnostic Translational Considerations for Global Health Settings: Portable Detection of Human Papillomavirus for Cervical Cancer Screening in India. 41043101 JCO Glob Oncol
Engineering Anti-Tumor Immunity: An Immunological Framework for mRNA Cancer Vaccines. 41441688 Vaccines (Basel)
High density diffusion-free nanowell arrays. 22742968 J Proteome Res
High-throughput cloning and expression library creation for functional proteomics. 23457047 Proteomics
Human Autoantigen Atlas: Searching for the Hallmarks of Autoantigens. 37183442 J Proteome Res
Identification of anti-Epstein-Barr virus (EBV) antibody signature in EBV-associated gastric carcinoma. 33661412
Identification of anti-Helicobacter pylori antibody signatures in gastric intestinal metaplasia. 36301365
Identification of Antibody Biomarker Using High-Density Nucleic Acid Programmable Protein Array. 34115351
Immunoprofiling using NAPPA protein microarrays. 21370064 Methods Mol Biol
Improving international research with clinical specimens: 5 achievable objectives. 22998582 J Proteome Res
Is 2045 the best we can do? Mitigating the HPV-related oropharyngeal cancer epidemic. 35679626 Expert Rev Anticancer Ther
Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays. 31710025
Microreactor array device. 25736721
Multiplexed detection of antibodies using programmable bead arrays. 21370069 Methods Mol Biol
Multiplexed Nucleic Acid Programmable Protein Arrays. 29109798
Next-generation high-density self-assembling functional protein arrays. 18469824 Nat Methods
Nucleic acid programmable protein array a just-in-time multiplexed protein expression and purification platform. 21943897 Methods Enzymol
Nucleic Acid Programmable Protein Arrays for Autoantibody Discovery: A Step-by-Step Guide. 41085633 Methods Mol Biol
p53 autoantibodies as potential detection and prognostic biomarkers in serous ovarian cancer. 20200435 Cancer Epidemiol Biomarkers Prev
Plasma Autoantibodies Associated with Basal-like Breast Cancers. 26070530
Pre-vaccine sentinel antibodies predict blunted vaccine responses. 42746633 Cell Press Blue
Prospective Study of Supplemental Screening With Contrast-Enhanced Mammography in Women With Elevated Risk of Breast Cancer: Results of the Prevalence Round. 39058970
Protein microarray signature of autoantibody biomarkers for the early detection of breast cancer. 20977275 J Proteome Res
Protein Microarray-Based Proteomics for Disease Analysis. 34115348
Protein Microarrays and their Fabrication. 36374419
Proteomic mapping of p53 immunogenicity in pancreatic, ovarian, and breast cancers. 27121307
Quantifying antibody binding on protein microarrays using microarray nonlinear calibration. 23662896
Quantitative assessment of multiple pathogen exposure and immune dynamics at scale. 38063388
Rapid detection of antibodies in sera using multiplexed self-assembling bead arrays. 19732778 J Immunol Methods
Rapid on-chip nucleic acid extraction for point-of-care salivary diagnostics. 40336490 Anal Methods
Robust microarray production of freshly expressed proteins in a human milieu. 23027544 Proteomics Clin Appl
Screening for oropharyngeal cancer: the time is now. 40116792 Expert Rev Mol Diagn
Serological profiling of Crohn's disease and ulcerative colitis patients reveals anti-microbial antibody signatures. 36157118 World J Gastroenterol
Serum antibodies to the HPV16 proteome as biomarkers for head and neck cancer. 21654689 Br J Cancer
Serum autoantibodyome reveals that healthy individuals share common autoantibodies. 35649350
Serum profiling of the antibody response to HPV in women with or without abnormal cervical cytology undergoing cervical cancer screening. 40821832 Front Immunol
The electrostatic landscape of MHC-peptide binding revealed using inception networks. 38554709 Cell Syst
The feasibility of using an autologous GM-CSF-secreting breast cancer vaccine to induce immunity in patients with stage II-III and metastatic breast cancers. 35482127 Breast Cancer Res Treat
The Immune System and the Proteome. 28056507
The integrin alpha(v)beta(3-5) ligand MFG-E8 is a p63/p73 target gene in triple-negative breast cancers but exhibits suppressive functions in ER(+) and erbB2(+) breast cancers. 21127199 Cancer Res
The sentinel within: exploiting the immune system for cancer biomarkers. 16083262 J Proteome Res
Tumor vaccines for breast cancer. 19358018 Cancer Invest

Interests

Autoantibodies and early detection
We are are interested in the use of autoantibodies for early detection of cancer. We use protein microarrays and a new technology called, multiplexed in solution protein arrays, to test various antigens as candidates for detecting autoantibodies. We are interested in studying all cancers, and have already extensively investigated breast cancer, basal-like breast cancer, ovarian cancer, lung cancer, head and neck cancer and some colon cancer.

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Photograph of LaBaer, Joshua
Site
Arizona State University
Degree(s)
M.D., Ph.D.
Email
jlabaer@asu.edu
Fax
(480) 965-3051
Person ID
1898
Note
To update contact information, please visit the Data Management and Coordinating Center .