Abbreviated Name

Biomarker Detection Using NAPPA Tumor Antigen Arrays

Lead Investigator

LaBaer, Joshua — Arizona State University

Coordinating Investigator

Anderson, Karen — Arizona State University

Involved Investigators

• Anderson, Karen — Arizona State University
• Marks, Jeffrey — Duke University Medical Center
• LaBaer, Joshua — Arizona State University
• Engstrom, Paul — Fox Chase Cancer Center

Abstract

No abstract availalbe.

Aims

Aim 1: Optimize NAPPA as a cancer autoantibody detection platform Aim 2: Identify tumor antigen-specific antibodies in a test set of early-stage breast cancer patient sera Aim 3: Validate the detection of tumor antigen-specific antibodies in early-stage breast cancer patient sera.

Analytic Method

Protein microarray and ELISA assays

Comments

No comments available.

Outcome

see associated publication

Secure Outcome

No secure outcome available.

Publications

• Protein microarray signature of autoantibody biomarkers for the early detection of breast cancer.

Biomarkers

• ALG10
• ATF3
• ATP6AP1
• BDNF
• BMX
• C15orf48
• CSNK1E
• CTBP1
• DBT
• EIF3E
• FRS3
• GPANK1
• GPR157
• HOXD1
• MYOZ2
• PDCD6IP
• RAB5A
• RAC3
• SELL
• SERPINH1
• SF3A1
• SLC33A1
• SOX2
• TFCP2
• TRIM32
• UBAP1
• ZMYM6
• ZNF510

Data Collections

• No data collections available at this time for this protocol.

Start Date

Aug 1 2005

Estimated Finish Date

Aug 1 2010

Finish Date

Jul 2 2010

Protocol ID

401

Protocol Type

Collaboration

Fields of Research

• Proteomics

Collaborative Group

Breast and Gynecologic Cancers Research Group

Cancer Types

• Malignant neoplasm of breast

Phased Status

1