Brand, Randall E.

Open Protocols

Protocol Name Investigatory Role Biomarkers Data Collections
A Prospective Study to Establish a New Onset Hyperglycemia and Diabetes (NOD) Cohort Involved 0 0
Biomarkers for early detection of pancreatic cancer Involved 0 1
Biomarkers for the Early Detection of Pancreatic Cancer Involved 0 0
Development of Tissue Microarray Resource for Pancreatic Cancer Leading 0 0
Pancreatic Cyst Biomarker Validation Study Bake Off Leading 23 0
Pancreatic Cystic Fluid Reference Set Leading 0 0
Pre-diagnostic Pancreatic Cancer Set Aside Project Leading 25 0
Technical and clinical validation of imaging biomarkers for early detection of pancreatic cancer Involved 0 0

Closed Protocols

Protocol Name Investigatory Role Biomarkers Data Collections
A Biomarker Bakeoff in Early Stage Pancreatic Cancer Involved 11 0
Pancreatic Cancer Bake Off 2 Leading 4 0
Standard Specimen Reference Set: Pancreatic Leading 0 0

Publications

Publication NamePubMed IDJournal
A Biomarker Panel for the Detection of Pancreatic Cancer. 42122194 Cancers (Basel)
A Combined DNA/RNA-based Next-Generation Sequencing Platform to Improve the Classification of Pancreatic Cysts and Early Detection of Pancreatic Cancer Arising From Pancreatic Cysts. 37212422 Ann Surg
A Novel HOXA10-Associated 5-Gene-Based Prognostic Signature for Stratification of Short-term Survivors of Pancreatic Ductal Adenocarcinoma. 37432996 Clin Cancer Res
A Novel HRD Signature Is Predictive of FOLFIRINOX Benefit in Metastatic Pancreatic Cancer. 37354528 Oncologist
A rigorous multi-laboratory study of known PDAC biomarkers identifies increased sensitivity and specificity over CA19-9 alone. 39276915
A timeless chronicle: Effects of cigarette smoke on GPR15 receptor and its oncogenic potential. 41412210 Cancer Lett
Accurate Identification of Mucinous Pancreatic Cystic Lesions Using Small-Volume Analytes. 36369049 J Surg Res
Cancer-Associated Fibroblast Induces Acinar-to-Ductal Cell Transdifferentiation and Pancreatic Cancer Initiation Via LAMA5/ITGA4 Axis. 38154529 Gastroenterology
Chemokine-mucinome interplay in shaping the heterogeneous tumor microenvironment of pancreatic cancer. 35346803 Semin Cancer Biol
Chimeric antibody targeting unique epitope on onco-mucin16 reduces tumor burden in pancreatic and lung malignancies. 37567918 NPJ Precis Oncol
Clinical and Molecular Attributes and Evaluation of Pancreatic Cystic Neoplasm. 36535512 Biochim Biophys Acta Rev Cancer
Confirmatory Clinical Validation of a Serum-Based Biomarker Signature for Detection of Early-Stage Pancreatic Ductal Adenocarcinoma. 41294700 Curr Oncol
Cytokines chattering in pancreatic ductal adenocarcinoma tumor microenvironment. 35346801 Semin Cancer Biol
Differential extracellular vesicle concentration and their biomarker expression of integrin α<sub>v</sub>/β<sub>5</sub>, EpCAM, and glypican-1 in pancreatic cancer models. 38902362 Sci Rep
Distinct glycosyltransferase expression governs organ-specific survival in pancreatic cancer metastasis. 42533113 Oncogene
Early detection of pancreatic cancer: Study design and analytical considerations in biomarker discovery and early phase validation studies. 39516175 Pancreatology
Emerging pathways yielding opportunities for future treatments in pancreatic ductal adenocarcinoma. 40382194 Expert Opin Ther Targets
Emerging Trends in Gastrointestinal Cancer Targeted Therapies: Harnessing Tumor Microenvironment, Immune Factors, and Metabolomics Insights. 38759843 Gastroenterology
GPCRs and fibroblast heterogeneity in fibroblast-associated diseases. 37486603 FASEB J
Immune checkpoint blockade in pancreatic cancer: Trudging through the immune desert. 36041672 Semin Cancer Biol
Muc16 depletion diminishes KRAS-induced tumorigenesis and metastasis by altering tumor microenvironment factors in pancreatic ductal adenocarcinoma. 36271032 Oncogene
MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion. 35533267 Mol Cancer Res
Muc4 loss mitigates epidermal growth factor receptor activity essential for PDAC tumorigenesis. 36624189 Oncogene
Mucin 5ac modulates cancer-associated fibroblast heterogeneity through epigenetic reprogramming of precursor cells. 41196138 Am J Physiol Cell Physiol
Mucin 5AC Serves as the Nexus for β-Catenin/c-Myc Interplay to Promote Glutamine Dependency During Pancreatic Cancer Chemoresistance. 34534538 Gastroenterology
Mucins as Potential Biomarkers for Early Detection of Cancer. 36980526 Cancers (Basel)
Multiplexed glycan immunofluorescence identification of pancreatic cancer cell subpopulations in both tumor and blood samples. 40053601 Sci Adv
Multiplexed Glycan Immunofluorescence Identification of Pancreatic Cancer Cell Subpopulations in Both Tumor and Blood Samples. 39229066 bioRxiv
PAF1 cooperates with YAP1 in metaplastic ducts to promote pancreatic cancer. 36180487 Cell Death Dis
Pancreatic Cysts Greater Than 1 cm Are Associated With an Increased Risk for Developing Pancreatic Cancer in Individuals From Pancreatic-Cancer Prone Kindreds Undergoing Surveillance. 38518061 Pancreas
Pathophysiological role of histamine signaling and its implications in glioblastoma. 38955315 Biochim Biophys Acta Rev Cancer
Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts. 36209796 Gastroenterology
RNA Sequencing Identifies Frequent Mitogen-activated Protein Kinase-associated Fusion Genes in Intraductal Tubulopapillary Neoplasms of the Pancreas. 36801389 Gastroenterology
Roles unveiled for membrane-associated mucins at the ocular surface using a Muc4 knockout mouse model. 37604830 Sci Rep
Secretory Trefoil Factor 1 (TFF1) promotes gemcitabine resistance through chemokine receptor CXCR4 in Pancreatic Ductal Adenocarcinoma. 38964729 Cancer Lett
SLC22A3/OCT3 drives serotonin-mediated stemness in pancreatic cancer. 42250222 Cell Rep
Small molecule inhibitor against onco-mucins disrupts Src/FosL1 axis to enhance gemcitabine efficacy in pancreatic ductal adenocarcinoma. 36285687 Cancer Lett
Substituent Effects Impact Surface Charge and Aggregation of Thiophenol-Labeled Gold Nanoparticles for SERS Biosensors. 35049653 Biosensors (Basel)
Sugar symphony: glycosylation in cancer metabolism and stemness. 39462722 Trends Cell Biol
Targeting cancer-associated fibroblast-driven LIF/LIFR axis improves the therapeutic efficacy of gemcitabine and nab-paclitaxel in pancreatic cancer. 40846751 NPJ Precis Oncol
Targeting Oncomucin-Driven Immunosuppression Improves the Efficacy of K-ras<sup>G12D</sup> Inhibition in Pancreatic Cancer. 42191046 Gastroenterology
Targeting the DDX3/PAF1 axis enhances chemotherapy efficacy in pancreatic ductal adenocarcinoma. 41581643 Cancer Lett
The underexplored complexity of pancreatic cancer: Early dissemination and quiescence. 42134624 Biochim Biophys Acta Rev Cancer
Unveiling the gut-pancreas axis: microbial influence on stemness and tumor microenvironment of PDAC. 41014502 Stem Cells
Unveiling the resistance to therapies in pancreatic ductal adenocarcinoma. 39243602 Drug Resist Updat
Validation of a Serum-Based Biomarker Signature for Detection of Early-Stage Pancreatic Ductal Adenocarcinoma. 41143761 Gastroenterology

Interests

Pancreatic Cancer
Interested in the development of pancreatic cancer biomarkers to assist in the management of patients at high risk for pancreatic cancer development including those with hereditary disorders and pancreatic cystic lesions.

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Photograph of Brand, Randall E.
Site
University of Pittsburgh
Degree(s)
M.D.
Email
reb53@pitt.edu
Fax
412-623-7828
Person ID
1525
EDRN Title
EDRN Principal Investigator
Note
To update contact information, please visit the Data Management and Coordinating Center .