Open Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
Biomarkers for the Early Detection of Pancreatic Cancer	Involved	0	0
Pancreatic Cyst Biomarker Validation Study Bake Off	Involved	23	0
Pre-diagnostic Pancreatic Cancer Set Aside Project	Involved	25	0
Validation of plasma biomarker panels for the early detection of pancreatic cancer	Leading	0	0

Closed Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
A Biomarker Bakeoff in Early Stage Pancreatic Cancer	Leading	11	0
Early Diagnosis of Pancreatic Cancer-Network Collaborative Studies	Involved	0	0
Pancreatic Cancer Bake Off 2	Involved	4	0
Pancreatic Reference Set Application: Brian Haab-Van Andel (2012)	Leading	2	0
Prostate Rapid Pre-Validation Set	Involved	6	0
Prostate Rapid Reference Set Application: Brian Haab - Van Andel (2006)	Leading	3	1

Publications

Publication Name	PubMed ID	Journal
A Gastric Glycoform of MUC5AC Is a Biomarker of Mucinous Cysts of the Pancreas.	27992432	PLoS One
A Novel Mass Spectrometry Platform for Multiplexed N-Glycoprotein Biomarker Discovery from Patient Biofluids by Antibody Panel Based N-Glycan Imaging.	31177770	Anal Chem
Advances in Tools to Determine the Glycan-Binding Specificities of Lectins and Antibodies.	31848260	Mol Cell Proteomics
Automated Identification and Quantification of Signals in Multichannel Immunofluorescence Images: The SignalFinder-IF Platform.	31026417	Am J Pathol
Characterization of glycoproteins in pancreatic cyst fluid using a high-performance multiple lectin affinity chromatography platform.	24303806	J Proteome Res
Characterizing Protein Glycosylation through On-Chip Glycan Modification and Probing.	27809484	Anal Chem
Chemically-blocked antibody microarray for multiplexed high-throughput profiling of specific protein glycosylation in complex samples.	22588202	J Vis Exp
Comparison of surgical and endoscopic sample collection for pancreatic cyst fluid biomarker identification.	22439797	J Proteome Res
Cyst fluid interleukin-1beta (IL1beta) levels predict the risk of carcinoma in intraductal papillary mucinous neoplasms of the pancreas.	21266527	Clin Cancer Res
Deciphering Protein Glycosylation by Computational Integration of On-chip Profiling, Glycan-array Data, and Mass Spectrometry.	30257876	Mol Cell Proteomics
Definitive Characterization of CA 19-9 in Resectable Pancreatic Cancer Using a Reference Set of Serum and Plasma Specimens.	26431551	PLoS One
Determining lectin specificity from glycan array data using motif segregation and GlycoSearch software.	23839995	Curr Protoc Chem Biol
Diverse monoclonal antibodies against the CA 19-9 antigen show variation in binding specificity with consequences for clinical interpretation.	22623153	Proteomics
Global comparisons of lectin-glycan interactions using a database of analyzed glycan array data.	23399549	Mol Cell Proteomics
Glycan motif profiling reveals plasma sialyl-lewis x elevations in pancreatic cancers that are negative for sialyl-lewis A.	25733690	Mol Cell Proteomics
Glycans related to the CA19-9 antigen are elevated in distinct subsets of pancreatic cancers and improve diagnostic accuracy over CA19-9.	26998508	Cell Mol Gastroenterol Hepatol
High-throughput studies of protein glycoforms using antibody-lectin sandwich arrays.	21901603	Methods Mol Biol
Identification of blood-protein carriers of the CA 19-9 antigen and characterization of prevalence in pancreatic diseases.	21751362	Proteomics
Mining High-Complexity Motifs in Glycans: A New Language To Uncover the Fine Specificities of Lectins and Glycosidases.	29058413	Anal Chem
Modulation of glycan detection on specific glycoproteins by lectin multimerization.	23286506	Anal Chem
Prediction of glycan motifs using quantitative analysis of multi-lectin binding: Motifs on MUC1 produced by cultured pancreatic cancer cells.	23956151	Proteomics Clin Appl
Segment and fit thresholding: a new method for image analysis applied to microarray and immunofluorescence data.	26339978	Anal Chem
Specific glycoforms of MUC5AC and endorepellin accurately distinguish mucinous from nonmucinous pancreatic cysts.	23836919	Mol Cell Proteomics
The CA19-9 and Sialyl-TRA Antigens Define Separate Subpopulations of Pancreatic Cancer Cells.	28642461	Sci Rep
The detection and discovery of glycan motifs in biological samples using lectins and antibodies: new methods and opportunities.	25727148	Adv Cancer Res
The development of an integrated platform to identify breast cancer glycoproteome changes in human serum.	19782370	J Chromatogr A
The fine specificity of mannose-binding and galactose-binding lectins revealed using outlier motif analysis of glycan array data.	21875884	Glycobiology
The Marker State Space (MSS) method for classifying clinical samples.	23750276	PLoS One
Upregulation of glycans containing 3' fucose in a subset of pancreatic cancers uncovered using fusion-tagged lectins.	25938165	J Proteome Res
Using antibody arrays to measure protein abundance and glycosylation: considerations for optimal performance.	24510592	Curr Protoc Protein Sci
Using lectins in biomarker research: addressing the limitations of sensitivity and availability.	22927350	Proteomics Clin Appl

Interests

Pancreatic cancer

Biomarkers for pancreatic cancer

Glycosylation

I am interested in characterizing the glycan variants that are associated with cancer and that can be measured as biomarkers.

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Site

Van Andel Research Institute

Degree(s)

Ph.D.

Email

brian.haab@vai.org

Person ID

1720

EDRN Title

EDRN Associate Member

Note

To update contact information, please visit the Data Management and Coordinating Center .