Open Protocols
Closed Protocols
Publications
No publications found at the present moment.
Interests
- Nuclear matrix proteins
- Robert H. Getzenberg, Ph.D., is The Donald S. Coffey Professor and Director of Urology Research,
Brady Urological Institute and Professor of Urology, Oncology and Pharmacology and Molecular Sciences at The Johns Hopkins University School of Medicine. Dr. Getzenberg's laboratory investigates translational aspects of cancer focusing on elements of cancer pathobiology that have direct clinical implications. His primary research interest is the focused proteomic study of one of the hallmarks of the cancer cell, altered nuclear structure. Specifically, what components of the nuclear scaffolding, the nuclear matrix, are different when comparing the cancer cell to its normal counterpart, and what role these components play both directly and indirectly in transformation. Proteomic analyses of signatures of the cancer process are permitting the developing of specific biomarkers for these diseases. Current research in Dr. Getzenberg's laboratory focuses on understanding the role of the nuclear matrix in the pathobiology of urologic and GI cancers and in developing cancer biomarkers focusing on these diseases. This work has been extended recently to include analysis of gene expression patterns associated with BPH and prostate cancer and in developing novel biomarkers and treatment strategies based on this approach.
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