Aliases

• B cell stimulatory factor-2
• B-cell differentiation factor
• B-cell stimulatory factor 2
• BSF-2
• BSF2
• CDF
• CTL differentiation factor
• HGF
• HSF
• Hybridoma growth factor
• IFN-beta-2
• IFNB2
• IL-6
• IL6
• Interferon beta-2
• Interleukin 6
• interleukin 6 (interferon, beta 2)

Description

Interleukin 6 (IL6) is a cytokine that is involved in inflammation and the maturation of B cells as well as induction of the acute phase response. In addition to inducing myeloma and plasmacytoma growth and nerve cell differentiation, it also plays an important role in the differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. The IL6 protein is produced mainly at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The IL6 gene is involved in many inflammation-associated disease states, including diabetes mellitus, where it acts on insulin resistance, and systemic juvenile rheumatoid arthritis. IL6 is discharged into the bloodstream after muscle contraction.

Attributes

QA State

Curated

Type

Proteomic

HGNC Name

IL6