Abbreviated Name

Pancreatic Ref Set App: Blasutig (2014)

Lead Investigator

Blasutig, Ivan — University of Toronto

Coordinating Investigator

Zheng, Yingye — Fred Hutchinson Cancer Center

Involved Investigators

• Blasutig, Ivan — University of Toronto
• Zheng, Yingye — Fred Hutchinson Cancer Center

Abstract

See objectives

Aims

We hypothesize that our candidate biomarkers can be used as a panel that will perform better than CA19.9 alone for the early detection of PDAC

Analytic Method

Comparisons of marker levels between groups were performed using the Mann Whitney-Wilcoxon test. Mean level comparisons were performed using a t-test and/or an ANOVA test.

Comments

No comments available.

Outcome

The Pancreatic Cancer Reference Set includes a large cohort of early stage pancreatic cancer patients, recruited from 5 different institutions, and relevant control groups including healthy controls, subjects with chronic pancreatitis, and subjects with acute benign biliary obstruction. For various biomarkers measured using plasma or serum samples collected in the pancreatic cancer reference set, we conducted statistical analyses evaluating each biomarker’s classification performance, as characterized by the Receiver Operating Characteristic curve and the optimal sensitivity + specificity, to separate each control group from all pancreatic cancer patients, from stage-I and IIa pancreatic cancer patients, or from stage IIb pancreatic cancer patients. Classification performances were reported for individual biomarkers, and for regression models combining biomarkers and CA-19-9, with or without adjusting for individual’s age and diabetes status. Bootstrap confidence intervals were reported for biomarkers’ performance and their incremental values over CA19-9. Analysis reports were generated separately for each lab.

Secure Outcome

No secure outcome available.

Publications

• No publications available at this time for this protocol.

Biomarkers

• AGR2
• CA125
• CA19-9
• CUZD16
• LAMC2
• REG1B
• SYCN

Data Collections

• No data collections available at this time for this protocol.

 Team Project

Start Date

Jul 24 2014

Estimated Finish Date

Nov 24 2014

Finish Date

May 2 2015

Protocol ID

389

Protocol Type

Reference Set

Fields of Research

• Proteomics

Collaborative Group

G.I. and Other Associated Cancers Research Group

Cancer Types

• Malignant neoplasm of pancreas

Phased Status

1