Open Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
BDL Colon Biomarker Development	Coordinating	1	0
BDL Esophageal Biomarker Development	Leading	1	2
Biomarkers of Risk for Colorectal Neoplasia (Team Project #2)	Involved	0	0
Targeted Sequencing for Discovery and Validation of DNA Methylation Markers of Colon Cancer Metastasis	Leading	0	0

Closed Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
Preliminary Validation of Biomarkers for the Detection of Colorectal Adenomas (Team Project #1)	Involved	1	0

Publications

Publication Name	PubMed ID	Journal
A Novel Blood-Based Colorectal Cancer Diagnostic Technology Using Electrical Detection of Colon Cancer Secreted Protein-2.	31179210	Adv Sci (Weinh)
Aberrant vimentin methylation is characteristic of upper gastrointestinal pathologies.	22315367	Cancer Epidemiol Biomarkers Prev
AGA Clinical Practice Guideline on Endoscopic Eradication Therapy of Barrett's Esophagus and Related Neoplasia.	38763697
Allele-specific expression of TGFBR1 in colon cancer patients.	20705955	Carcinogenesis
Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD).	24760190	Sci Transl Med
Cancer bypasses the lymph nodes.	28684492	Science
Colonic 15-PGDH levels are stable across distance and time and are not perturbed by aspirin intervention.	23625286	Dig Dis Sci
Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer.	24793120	Gastroenterology
DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination.	21045206	Sci Signal
Emerging paradigms for the initiation of mucin-type protein O-glycosylation by the polypeptide GalNAc transferase family of glycosyltransferases.	21349845	J Biol Chem
Epigenomic enhancer profiling defines a signature of colon cancer.	22499810	Science
Evaluation of Patients with an Apparent False Positive Stool DNA Test: The Role of Repeat Stool DNA Testing.	29516325	Dig Dis Sci
Genetic variation in 15-hydroxyprostaglandin dehydrogenase and colon cancer susceptibility.	23717544	PLoS One
Global mutational profiling of formalin-fixed human colon cancers from a pathology archive.	22878650	Mod Pathol
Identifying DNA methylation biomarkers for non-endoscopic detection of Barrett's esophagus.	29343623	Sci Transl Med
Inhibition of 15-hydroxyprostaglandin dehydrogenase by Helicobacter pylori in human gastric carcinogenesis.	23430757	Cancer Prev Res (Phila)
Methylated B3GAT2 and ZNF793 Are Potential Detection Biomarkers for Barrett's Esophagus.	26545406	Cancer Epidemiol Biomarkers Prev
Molecular Imaging of Colorectal Tumors by Targeting Colon Cancer Secreted Protein-2 (CCSP-2).	28886423	Neoplasia
MULTICENTER, PROSPECTIVE TRIAL OF NON-ENDOSCOPIC BIOMARKER-DRIVEN DETECTION OF BARRETT'S ESOPHAGUS AND ESOPHAGEAL ADENOCARCINOMA.	38686933
NTRK3 is a potential tumor suppressor gene commonly inactivated by epigenetic mechanisms in colorectal cancer.	23874207	PLoS Genet
Pandemic-Related Changes in Incidence and Mortality Rates of Gastrointestinal Cancers During 2020.	37791616
Patients With Esophageal Adenocarcinoma With Prior Gastroesophageal Reflux Disease Symptoms Are Similar to Those Without Gastroesophageal Reflux Disease: A Cross-Sectional Study.	37975600
Performance of multitarget stool DNA testing in African American patients.	30193399	Cancer
RNA Sequencing Identifies Transcriptionally Viable Gene Fusions in Esophageal Adenocarcinomas.	27503924	Cancer Res
Subtypes of Barrett's oesophagus and oesophageal adenocarcinoma based on genome-wide methylation analysis.	29884612	Gut
Systems Biology Analyses Show Hyperactivation of Transforming Growth Factor-β and JNK Signaling Pathways in Esophageal Cancer.	30768984	Gastroenterology
The microRNAs, MiR-31 and MiR-375, as candidate markers in Barrett's esophageal carcinogenesis.	22302717	Genes Chromosomes Cancer
The molecular pathogenesis of colorectal cancer and its potential application to colorectal cancer screening.	25492499	Dig Dis Sci
Transposon mutagenesis identifies candidate genes that cooperate with loss of transforming growth factor-beta signaling in mouse intestinal neoplasms.	27790711	Int J Cancer

Interests

Colon Cancer

None

DNA Methylation

None

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Site

Case Western Reserve University

Degree(s)

M.D., Ph.D.

Email

sxm10@po.cwru.edu

Fax

213-844-8230

Person ID

1498

EDRN Title

EDRN Principal Investigator

Note

To update contact information, please visit the Data Management and Coordinating Center .