Open Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
An Automated System for Breast Cancer Biomarker Analysis	Leading	0	1
Automated Quantitative Measures of Breast Density	Leading	1	2
Moffitt Imaging Biomarker Validation Center	Leading	0	0
Standard Specimen Reference Set: Breast Cancer and Imaging	Involved	0	0

Closed Protocols

This person has no closed protocols at the present moment.

Publications

Publication Name	PubMed ID	Journal
A Radiogenomics Ensemble to Predict EGFR and KRAS Mutations in NSCLC.	33946756
Advancements in an Automated Breast Density Detection Technique for Breast Cancer Risk Prediction: a Synthetic Signal-dependent Noise Construct.	41394558	bioRxiv
Association between Inflammatory Dietary Pattern and Mammographic Features.	39277115	J Nutr
Associations of Oral Contraceptives with Mammographic Breast Density in Premenopausal Women.	34862209
Breast density analysis of digital breast tomosynthesis.	37907569
Breast Density Analysis Using Digital Breast Tomosynthesis.	36824710	bioRxiv
Calibrated Breast Density Measurements.	30545682	Acad Radiol
Challenges in Using Deep Neural Networks Across Multiple Readers in Delineating Prostate Gland Anatomy.	40392414	J Imaging Inform Med
Clinical AI in Radiology: Foundations, Trends, Applications, and Emerging Directions.	41899545	Cancers (Basel)
Computed Tomography-Based Radiomics Features Characterize Low and High-Risk Lung Cancer Among People Living With HIV: An Early Report.	41564790	Clin Lung Cancer
Early-Life and Adult Anthropometrics in Relation to Mammographic Image Intensity Variation in the Nurses' Health Studies.	31826913	Cancer Epidemiol Biomarkers Prev
Employing Consensus-Based Reasoning with Locally Deployed LLMs for Enabling Structured Data Extraction from Surgical Pathology Reports.	40343037	medRxiv
Extracellular Microvesicle MicroRNAs and Imaging Metrics Improve the Detection of Aggressive Prostate Cancer: A Pilot Study.	40075682	Cancers (Basel)
Extracellular microvesicle microRNAs, along with imaging metrics, improve detection of aggressive prostate cancer.	39228742	medRxiv
Fourier Analysis of Bilateral Breast Asymmetry for Short-term Breast Cancer Risk Prediction.	41959806	medRxiv
Fourier analysis of signal dependent noise images.	39730404	Sci Rep
Generalized breast density metrics.	30523909	Phys Med Biol
Habitat Radiomics Predict HPV Status in Oropharyngeal Cancer.	41422495	Cancer Med
Mammographic Variation Measures, Breast Density, and Breast Cancer Risk.	34161135
Multimodal AI-driven Biomarker for Early Detection of Cancer Cachexia.	41001462	medRxiv
Novel risk models based on screening history results and timing of lung cancer diagnosis: <i>Post hoc</i> analysis of the National Lung Cancer Screening Trial.	42064909	medRxiv
Personalised Lung Cancer Screening (PLuS) study to assess the importance of coexisting chronic conditions to clinical practice and policy: protocol for a multicentre observational study.	35732383	BMJ Open
Plasma C-peptide mammographic features and risk of breast cancer.	39420200	NPJ Breast Cancer
Preoperative CT-Based Habitat Radiomics Classifiers Predict Recurrence in Non-Small Cell Lung Cancer.	42064931	medRxiv
Privacy-preserving Federated Learning and Uncertainty Quantification in Medical Imaging.	40366260	Radiol Artif Intell
Quantitative DCE Dynamics on Transformed MR Imaging Discriminates Clinically Significant Prostate Cancer.	39545376	Cancer Control
REASONING BEYOND ACCURACY: EXPERT EVALUATION OF LARGE LANGUAGE MODELS IN DIAGNOSTIC PATHOLOGY.	40297448	medRxiv
Reliable Radiologic Skeletal Muscle Area Assessment - A Biomarker for Cancer Cachexia Diagnosis.	40313262	medRxiv
Reliable Radiologic Skeletal Muscle Area Assessment-A Biomarker for Cancer Cachexia Diagnosis.	41892306	Cells
Reproductive Factors Related to Childbearing and a Novel Automated Mammographic Measure, V.	38497795
Self-Normalizing Multi-Omics Neural Network for Pan-Cancer Prognostication.	40806487	Int J Mol Sci
Spatial Correlation and Breast Cancer Risk.	33304615
Technical challenges in generalizing calibration techniques for breast density measurements.	30525207	Med Phys
Trans-omics gene-smoking interactions: a new framework for stratifying smoking-related lung cancer risk.	42085236	Am J Respir Crit Care Med
Utilizing Clinicopathological and Radiomic Features for Risk Stratification of Lung Cancer Recurrence.	40379589	Acad Radiol
Volume doubling time and radiomic features predict tumor behavior of screen-detected lung cancers.	35491768	Cancer Biomark

Interests

Validate image-based markers in screening and diagnostic mammography

Validate image-based markers in screening and diagnostic mammography. We will (1a) extend our generalized breast density measurements to multivariate ML/DL techniques for both risk prediction and early detection; (1b) further validate several diagnostic models in women classified as BI-RADS55 4 with ML/DL inclusive of blood analytes; and (1c) apply ML to quantify and predict the related diagnostic subcategories (i.e., BI-RADS 4 a, b, and c) as markers of malignancy.

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Site

H. Lee Moffitt Cancer Center & Research Institute, Inc.

Degree(s)

Ph.D.

Email

john.heine@moffitt.org

Person ID

3734

EDRN Title

EDRN Principal Investigator

Note

To update contact information, please visit the Data Management and Coordinating Center .