Open Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
Indeterminate pulmonary nodule biomarker clinical utility trial	Involved	0	0
LTP2 Results Analysis-Willey-Toledo-2024	Leading	0	0
Lung Cancer Risk Trial	Leading	0	0
Validation of Molecular Biomarkers for the Early Detection of Lung Cancer in the setting of Indeterminate Pulmonary Nodules (Lung Team Project #2)	Involved	15	1

Closed Protocols

This person has no closed protocols at the present moment.

Publications

Publication Name	PubMed ID	Journal
A 20-year Follow-up of the International Early Lung Cancer Action Program (I-ELCAP).	37934099
A lung cancer risk classifier comprising genome maintenance genes measured in normal bronchial epithelial cells.	28464886
A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency.	33863366
Advancing NGS quality control to enable measurement of actionable mutations in circulating tumor DNA.	35475002	Cell Rep Methods
Baseline and annual repeat rounds of screening: implications for optimal regimens of screening.	28983713
Control for stochastic sampling variation and qualitative sequencing error in next generation sequencing.	26693143
Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.	35915169
Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples.	35768876	Genome Biol
Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing.	34504347
Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology.	33846644
Evaluation of a National Quality Improvement Collaborative for Improving Cancer Screening.	36383381
Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk.	35138370
Haplotype and diplotype analyses of variation in ERCC5 transcription cis-regulation in normal bronchial epithelial cells.	27235448
New or enlarging hiatal hernias after thoracic surgery for early lung cancer.	36004265
Platelet-T cell aggregates in lung cancer patients: Implications for thrombosis.	32776968
Prospective Cohort Study to Compare Long-Term Lung Cancer-Specific and All-Cause Survival of Clinical Early Stage (T1a-b; ≤20 mm) NSCLC Treated by Stereotactic Body Radiation Therapy and Surgery.	37806384
Radiologic Features of Nodules Attached to the Mediastinal or Diaphragmatic Pleura at Low-Dose CT for Lung Cancer Screening.	38165250
RNAseq analysis of bronchial epithelial cells to identify COPD-associated genes and SNPs.	29506519	BMC Pulm Med
Survival with Parenchymal and Pleural Invasion of Non-Small Cell Lung Cancers Less than 30 mm.	30685507
Technical advance in targeted NGS analysis enables identification of lung cancer risk-associated low frequency TP53, PIK3CA, and BRAF mutations in airway epithelial cells.	31711466
The importance of low-dose CT screening to identify emphysema in asymptomatic participants with and without a prior diagnosis of COPD.	33799061
Toward best practice in cancer mutation detection with whole-genome and whole-exome sequencing.	34504346
TP53 mutation prevalence in normal airway epithelium as a biomarker for lung cancer risk.	37612638	BMC Cancer

Interests

No interests found at the present moment.

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Site

University of Toledo College of Medicine

Degree(s)

M.D.

Email

james.willey2@utoledo.edu

Person ID

3930

EDRN Title

EDRN Associate Member

Note

To update contact information, please visit the Data Management and Coordinating Center .