Open Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
Biomarkers for Lung Cancer in the Setting of Indeterminate Pulmonary Nodules	Leading	0	0
Indeterminate pulmonary nodule biomarker clinical utility trial	Involved	0	0
LTP2 Results Analysis Lenburg BU 2024	Involved	0	0
Validation of Molecular Biomarkers for the Early Detection of Lung Cancer in the setting of Indeterminate Pulmonary Nodules (Lung Team Project #2)	Leading	15	1

Closed Protocols

This person has no closed protocols at the present moment.

Publications

Publication Name	PubMed ID	Journal
A Bronchial Genomic Classifier for the Diagnostic Evaluation of Lung Cancer.	25981554	N Engl J Med
A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia.	27658890	Cancer Prev Res (Phila)
Alterations in Bronchial Airway miRNA Expression for Lung Cancer Detection.	28877936	Cancer Prev Res (Phila)
Characterizing the impact of smoking and lung cancer on the airway transcriptome using RNA-Seq.	21636547	Cancer Prev Res (Phila)
Clinical Utility of a Bronchial Genomic Classifier in Patients With Suspected Lung Cancer.	26896702	Chest
Cost-effectiveness analysis of LungLB for the clinical management of patients with indeterminate pulmonary nodules.	36802981
Derivation of a bronchial genomic classifier for lung cancer in a prospective study of patients undergoing diagnostic bronchoscopy.	25944280	BMC Med Genomics
Detecting the Presence and Progression of Premalignant Lung Lesions via Airway Gene Expression.	28533227	Clin Cancer Res
Electronic cigarettes: a task force report from the European Respiratory Society.	30464018	Eur Respir J
Expanding Role of Advanced Image Analysis in CT-detected Indeterminate Pulmonary Nodules and Early Lung Cancer Characterization.	37815447
Gene Expression Alterations in the Bronchial Epithelium of e-Cigarette Users.	31233743	Chest
MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis.	24158479	Proc Natl Acad Sci U S A
Molecular Impact of Electronic Cigarette Aerosol Exposure in Human Bronchial Epithelium.	27701119	Toxicol Sci
Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis.	24618292	Cancer Prev Res (Phila)
Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions.	31015447	Nat Commun
PGE2-driven expression of c-Myc and oncomiR-17-92 contributes to apoptosis resistance in NSCLC.	24469837	Mol Cancer Res
Shared Gene Expression Alterations in Nasal and Bronchial Epithelium for Lung Cancer Detection.	28376173	J Natl Cancer Inst
SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue.	22986747	Cancer Res
Tailoring pretext tasks to improve self-supervised learning in histopathologic subtype classification of lung adenocarcinomas.	37741228
The Airway Transcriptome as a Biomarker for Early Lung Cancer Detection.	29463557	Clin Cancer Res
The presence of circulating genetically abnormal cells in blood predicts risk of lung cancer in individuals with indeterminate pulmonary nodules.	37277788
Transportability Analysis-A Tool for Extending Trial Results to a Representative Target Population.	38289608

Interests

Lung Cancer Detection Biomarkers

We are developing biomarkers for lung cancer detection based on gene expression patterns in normal appearing airway epithelium (nasal and bronchial)

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Site

Boston University

Degree(s)

Ph.D.

Email

mlenburg@bu.edu

Person ID

2805

Note

To update contact information, please visit the Data Management and Coordinating Center .