Lenburg, Marc

Open Protocols

Protocol Name Investigatory Role Biomarkers Data Collections
Biomarkers for Lung Cancer in the Setting of Indeterminate Pulmonary Nodules Leading 0 0
Indeterminate pulmonary nodule biomarker clinical utility trial Involved 0 0
Validation of Molecular Biomarkers for the Early Detection of Lung Cancer in the setting of Indeterminate Pulmonary Nodules (Lung Team Project #2) Leading 15 0

Closed Protocols

Protocol Name Investigatory Role Biomarkers Data Collections
LTP2 Results Analysis Lenburg BU 2024 Leading 0 0

Publications

Publication NamePubMed IDJournal
A Bronchial Genomic Classifier for the Diagnostic Evaluation of Lung Cancer. 25981554 N Engl J Med
A comparative analysis of image harmonization techniques in mitigating differences in CT acquisition and reconstruction. 39823753 Phys Med Biol
A computed tomography-based score indicative of lung cancer aggression (SILA) predicts lung adenocarcinomas with low malignant potential or vascular invasion. 39058440 Cancer Biomark
A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia. 27658890 Cancer Prev Res (Phila)
Advancing Precision Oncology Through Modeling of Longitudinal and Multimodal Data. 40608875 IEEE Rev Biomed Eng
Alterations in Bronchial Airway miRNA Expression for Lung Cancer Detection. 28877936 Cancer Prev Res (Phila)
Alterations to the Bronchial Gene-Expression Effects of Tobacco Smoking in People Living With HIV. 41734085 J Acquir Immune Defic Syndr
Analyzing Patient Characteristics and Lung Cancer Outcomes Pre and Post the 2021 USPSTF Lung Cancer Screening Guidelines: Experience From a Large Academic Institution. 40685891 J Thorac Imaging
Archetype analysis of lung adenocarcinoma premalignancy links heterogeneity in premalignant lesions to diverging features of invasive disease. 42089783 Mol Cancer Res
Characterization of the cancer-associated field of injury in the nasal epithelium in never-smokers. 42349086 Lung Cancer
Characterizing the impact of smoking and lung cancer on the airway transcriptome using RNA-Seq. 21636547 Cancer Prev Res (Phila)
Clinical Utility of a Bronchial Genomic Classifier in Patients With Suspected Lung Cancer. 26896702 Chest
Combining graph neural network and Mamba to capture local and global tissue spatial relationships in whole slide images. 40415116 Sci Rep
Cost-effectiveness analysis of LungLB for the clinical management of patients with indeterminate pulmonary nodules. 36802981
DART: DEFORMABLE ANATOMY-AWARE REGISTRATION TOOLKIT FOR LUNG CT REGISTRATION WITH KEYPOINTS SUPERVISION. 39309597 Proc IEEE Int Symp Biomed Imaging
Derivation of a bronchial genomic classifier for lung cancer in a prospective study of patients undergoing diagnostic bronchoscopy. 25944280 BMC Med Genomics
Detecting the Presence and Progression of Premalignant Lung Lesions via Airway Gene Expression. 28533227 Clin Cancer Res
Electronic cigarettes: a task force report from the European Respiratory Society. 30464018 Eur Respir J
Evaluating the robustness of features generated by a foundation model from CT with different reconstruction parameters. 42038169 Proc SPIE Int Soc Opt Eng
Expanding Role of Advanced Image Analysis in CT-detected Indeterminate Pulmonary Nodules and Early Lung Cancer Characterization. 37815447
Gene Expression Alterations in the Bronchial Epithelium of e-Cigarette Users. 31233743 Chest
Interferon Epsilon Loss Is Elusive 9p21 Link to Immune-Cold Tumors, Resistant to Immune Checkpoint Therapy, and Endogenous CXCL9/10 Induction. 39725169 J Thorac Oncol
Lung cancer screening with low-dose computed tomography-where do we go from here? 39283712 J Natl Cancer Inst
MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis. 24158479 Proc Natl Acad Sci U S A
Molecular Impact of Electronic Cigarette Aerosol Exposure in Human Bronchial Epithelium. 27701119 Toxicol Sci
Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis. 24618292 Cancer Prev Res (Phila)
Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions. 31015447 Nat Commun
PGE2-driven expression of c-Myc and oncomiR-17-92 contributes to apoptosis resistance in NSCLC. 24469837 Mol Cancer Res
Reducing demographic bias in biomedical machine learning for cancer detection using cfDNA methylation. 41736096 Genome Biol
Shared Gene Expression Alterations in Nasal and Bronchial Epithelium for Lung Cancer Detection. 28376173 J Natl Cancer Inst
SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue. 22986747 Cancer Res
SmokeBERT: A Bidirectional Encoder Representations From Transformers-Based Model for Quantitative Smoking History Extraction From Clinical Narratives to Improve Lung Cancer Screening. 41325572 JCO Clin Cancer Inform
Tailoring pretext tasks to improve self-supervised learning in histopathologic subtype classification of lung adenocarcinomas. 37741228
The Airway Transcriptome as a Biomarker for Early Lung Cancer Detection. 29463557 Clin Cancer Res
The presence of circulating genetically abnormal cells in blood predicts risk of lung cancer in individuals with indeterminate pulmonary nodules. 37277788
Toward the simultaneous detection of multiple diseases with a highly cost-effective cell-free DNA methylome test. 41941615 Proc Natl Acad Sci U S A
Transportability Analysis-A Tool for Extending Trial Results to a Representative Target Population. 38289608
Upregulation of an Epithelial miRNA Is Associated with Immune Evasion in Progressive Bronchial Premalignant Lesions. 41670462 Cancer Immunol Res
Vision-language model-based semantic-guided imaging biomarker for lung nodule malignancy prediction. 41161557 J Biomed Inform

Interests

Lung Cancer Detection Biomarkers
We are developing biomarkers for lung cancer detection based on gene expression patterns in normal appearing airway epithelium (nasal and bronchial)

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Photograph of Lenburg, Marc
Site
Boston University
Degree(s)
Ph.D.
Email
mlenburg@bu.edu
Person ID
2805
Note
To update contact information, please visit the Data Management and Coordinating Center .