Grady, William

Open Protocols

Protocol Name Investigatory Role Biomarkers Data Collections
Biomarkers of Risk for Colorectal Neoplasia (Team Project #2) Involved 0 0
Using the methylome to identify aggressive Barrett’s esophagus Leading 0 0

Closed Protocols

This person has no closed protocols at the present moment.

Publications

Publication NamePubMed IDJournal
3D pathology-guided microdissection. 42332091 Nat Methods
Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model. 19777566 Mol Carcinog
Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps. 15709190 Clin Cancer Res
Aberrantly methylated PKP1 in the progression of Barrett's esophagus to esophageal adenocarcinoma. 22170739 Genes Chromosomes Cancer
Are Non-invasive Multi-cancer Early Cancer Detection Tests the Future? 39885052 Dig Dis Sci
Artificial Intelligence-Triaged 3-Dimensional Pathology to Improve Detection of Esophageal Neoplasia While Reducing Pathologist Workloads. 37657711 Mod Pathol
Assessing the Effects of a 3-Dimensional (3D) Pathology Tissue-Processing Workflow on Downstream Molecular Analyses. 42303047 Lab Invest
Assessment of familiality, obesity, and other risk factors for early age of cancer diagnosis in adenocarcinomas of the esophagus and gastroesophageal junction. 19491834 Am J Gastroenterol
CIMP and colon cancer gets more complicated. 17938428 Gut
Circulating tryptophan-kynurenine pathway metabolites are associated with all-cause mortality among patients with stage I-III colorectal cancer. 39308420 Int J Cancer
Clinical Validation of a Circulating Tumor DNA-Based Blood Test to Screen for Colorectal Cancer. 40455622 JAMA
Cohort profile: Biomarkers related to folate-dependent one-carbon metabolism in colorectal cancer recurrence and survival - the FOCUS Consortium. 36549742 BMJ Open
Colorectal cancer molecular biology moves into clinical practice. 20921207 Gut
Colorectal endoscopy, advanced adenomas, and sessile serrated polyps: implications for proximal colon cancer. 22688851 Am J Gastroenterol
Cost-Effectiveness of Liquid Biopsy for Colorectal Cancer Screening in Patients Who Are Unscreened. 37971743
CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer. 16708352 Genes Chromosomes Cancer
Deep-learning triage of three-dimensional pathology datasets for comprehensive and efficient pathologist assessments. 42587049 Nat Biomed Eng
Development, characterization, and inter-laboratory validation of methylated human cell free DNA candidate reference materials. 42152147 Clin Epigenetics
Discovery and Initial Characterization of Long Intergenic Noncoding RNAs Associated With Esophageal Adenocarcinoma. 37182784 Gastroenterology
DNA alkylation and DNA methylation: cooperating mechanisms driving the formation of colorectal adenomas and adenocarcinomas? 17339242 Gut
DNA methylation and gene expression profiling of ewing sarcoma primary tumors reveal genes that are potential targets of epigenetic inactivation. 23024594 Sarcoma
DNA methylation profile in CpG-depleted regions uncovers a high-risk subtype of early-stage colorectal cancer. 36171645 J Natl Cancer Inst
DNA methylation profiling across the spectrum of HPV-associated anal squamous neoplasia. 23226306 PLoS One
DNA methylation profiling in Barrett's esophagus and esophageal adenocarcinoma reveals unique methylation signatures and molecular subclasses. 22139570 Epigenetics
Elevated EVL Methylation Level in the Normal Colon Mucosa Is a Potential Risk Biomarker for Developing Recurrent Adenomas. 37294695 Cancer Epidemiol Biomarkers Prev
Emerging Tests for Noninvasive Colorectal Cancer Screening. 36539002 Clin Gastroenterol Hepatol
Epigenetic Alterations in Colitis-Associated Colorectal Cancer. 41562706 Epigenomes
Epigenetic biomarkers in esophageal cancer. 22406828 Cancer Lett
Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer. 18264139 Oncogene
Epigenetics and colorectal cancer. 22009203 Nat Rev Gastroenterol Hepatol
Epigenomic analysis of aberrantly methylated genes in colorectal cancer identifies genes commonly affected by epigenetic alterations. 21298349 Ann Surg Oncol
Evidence for the role of aberrant DNA methylation in the pathogenesis of Lynch syndrome adenomas. 17278092 Int J Cancer
Gastric (Foveolar)-Type Dysplasia in Barrett's Esophagus: A Clinical, Molecular, and Long-Term Outcome Study. 40162676 Am J Gastroenterol
Genomic aberrations occurring in subsets of serrated colorectal lesions but not conventional adenomas. 23539450 Cancer Res
Genomic and epigenetic instability in colorectal cancer pathogenesis. 18773902 Gastroenterology
Genomic instability and colorectal cancer. 17024019 Curr Opin Gastroenterol
Histopathology-based Spatial Profiling of Immune and Molecular Features Predicts Cancer risk in Barrett's Esophagus. 41292664 medRxiv
HNF4A Defines Molecular Subtypes and Vulnerability to Transforming Growth Factor β-Pathway Targeted Therapies in Cancers of the Distal Esophagus. 35934060 Gastroenterology
Inactivation of TGF-β signaling and loss of PTEN cooperate to induce colon cancer in vivo. 23604118 Oncogene
Insights into the role of DNA methylation in disease through the use of mouse models. 20427558 Dis Model Mech
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. 17349581 Cancer Cell
Linking epidemiology to epigenomics--where are we today? 21149325 Cancer Prev Res (Phila)
Making the case for DCC and UNC5C as tumor-suppressor genes in the colon. 18054576 Gastroenterology
Mapping the core senescence phenotype of primary human colon fibroblasts. 38385965
Molecular Analysis of Persistent and Recurrent Barrett's Esophagus in the Setting of Endoscopic Therapy. 39007490 Clin Transl Gastroenterol
Multiplex Digital PCR Assay Targeting DNA Methylation for Early Detection of Cancer. 41073857 Methods Mol Biol
Mutational inactivation of TGFBR2 in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming growth factor beta resistant cells. 17985359 Genes Chromosomes Cancer
Natural History of Colorectal Polyps Undergoing Longitudinal in Vivo CT Colonography Surveillance. 38289210
Novel DNA Methylation Biomarker Panel for Detection of Esophageal Adenocarcinoma and High-Grade Dysplasia. 35705525 Clin Cancer Res
Patients With Esophageal Adenocarcinoma With Prior Gastroesophageal Reflux Disease Symptoms Are Similar to Those Without Gastroesophageal Reflux Disease: A Cross-Sectional Study. 37975600
Pre-cancer: From diagnosis to intervention opportunities. 37037612 Cancer Cell
Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations. 16108056 Int J Cancer
Promoter methylation status of the MGMT, hMLH1, and CDKN2A/p16 genes in non-neoplastic mucosa of patients with and without colorectal adenomas. 16820927 Oncol Rep
Quality assessment and correlation of microsatellite instability and immunohistochemical markers among population- and clinic-based colorectal tumors results from the Colon Cancer Family Registry. 21497289 J Mol Diagn
RET is a potential tumor suppressor gene in colorectal cancer. 22751117 Oncogene
Significance of Crypt Atypia in Barrett's Esophagus: A Clinical, Molecular, and Outcome Study. 37879518 Clin Gastroenterol Hepatol
TGF-beta has paradoxical and context dependent effects on proliferation and anoikis in human colorectal cancer cell lines. 18651288 Growth Factors
TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. 19208363 Gastroenterology
TGF-beta receptor levels regulate the specificity of signaling pathway activation and biological effects of TGF-beta. 19339207 Biochim Biophys Acta
The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer. 18425817 Int J Cancer
The next thing in prognostic molecular markers: microRNA signatures of cancer. 20551450 Gut
Top advances of the year: Noninvasive colorectal cancer screening tests. 41045472 Cancer
Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. 17047044 Cancer Res

Interests

colon cancer biomarkers
Methylated genes as early detection markers for colon cancer and colon adenomas.
Colorectal cancer biomarkers
Methylated genes as risk markers and early detection markers for colon adenomas and adenocarcinomas
DNA methylation
Biomarkers for GI cancer
Barretts esophagus
Prognostic biomarkers for Barretts esophagus and esophageal adenocarcinoma

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Photograph of Grady, William
Site
Fred Hutchinson Cancer Center
Degree(s)
M.D.
Email
wgrady@fredhutch.org
Fax
206-667-2917
Person ID
1371
Note
To update contact information, please visit the Data Management and Coordinating Center .