Open Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
New Biomarkers & Dysplastic Respiratory Epithelium	Coordinating	0	0

Closed Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
EDRN Resource Network Exchange	Involved	0	0
Standard Specimen Reference Set: Lung	Involved	0	0

Publications

Publication Name	PubMed ID	Journal
A major lung cancer susceptibility locus maps to chromosome 6q23-25.	15272417	Am J Hum Genet
Analysis of c-ErbB1/epidermal growth factor receptor and c-ErbB2/HER-2 expression in bronchial dysplasia: evaluation of potential targets for chemoprevention of lung cancer.	16609045	Clin Cancer Res
Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model.	16314486	Am J Pathol
Antitumor activity of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib (ZD1839, Iressa) in non-small cell lung cancer cell lines correlates with gene copy number and EGFR mutations but not EGFR protein levels.	17145836	Clin Cancer Res
Baseline gene expression predicts sensitivity to gefitinib in non-small cell lung cancer cell lines.	16877703	Mol Cancer Res
Biological markers for non-small cell lung cancer patient selection for epidermal growth factor receptor tyrosine kinase inhibitor therapy.	16778092	Clin Cancer Res
Bronchioloalveolar carcinoma: a model for investigating the biology of epidermal growth factor receptor inhibition.	15217959	Clin Cancer Res
Chemoprevention of lung cancer--from biology to clinical reality.	14760107	Ann Oncol
Chromosomal aneusomy in bronchial high-grade lesions is associated with invasive lung cancer.	17989344	Am J Respir Crit Care Med
Combination of EGFR gene copy number and protein expression predicts outcome for advanced non-small-cell lung cancer patients treated with gefitinib.	17317677	Ann Oncol
Comparative analysis of algorithms for signal quantitation from oligonucleotide microarrays.	14751998	Bioinformatics
EGFR-mutant lung adenocarcinoma in a patient with Li-Fraumeni syndrome.	17540308	Lancet Oncol
Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer.	15870435	J Natl Cancer Inst
Epidermal growth factor receptor gene copy number and protein level are not associated with outcome of non-small-cell lung cancer patients treated with chemotherapy.	17082511	Ann Oncol
Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis.	12953099	J Clin Oncol
Epidermal growth factor receptor messenger RNA expression, gene dosage, and gefitinib sensitivity in non-small cell lung cancer.	16707605	Clin Cancer Res
EU-USA pathology panel for uniform diagnosis in randomised controlled trials for HRCT screening in lung cancer.	16899486	Eur Respir J
Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma.	15886315	J Clin Oncol
Gefitinib therapy in advanced bronchioloalveolar carcinoma: Southwest Oncology Group Study S0126.	16622257	J Clin Oncol
HER3 genomic gain and sensitivity to gefitinib in advanced non-small-cell lung cancer patients.	16288303	Br J Cancer
High prevalence of endobronchial malignancy in high-risk patients with moderate dysplasia in sputum.	15136448	Chest
High prevalence of occult endobronchial malignancy in high risk patients with moderate sputum atypia.	16022912	Lung Cancer
Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a Southwest Oncology Group Study.	15998906	J Clin Oncol
Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients.	16051952	J Clin Oncol
Insulin-like growth factor receptor 1 (IGFR-1) is significantly associated with longer survival in non-small-cell lung cancer patients treated with gefitinib.	16600976	Ann Oncol
Molecular classification and molecular genetics of human lung cancers.	14981576	Semin Oncol
Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer.	17075123	J Clin Oncol
Multi-target interphase fluorescence in situ hybridization assay increases sensitivity of sputum cytology as a predictor of lung cancer.	15350627	Cancer Detect Prev
Nuclear accumulation of beta-catenin occurs commonly in the epithelial cells of juvenile polyps.	15557107	Pediatr Res
Overexpression of vascular endothelial growth factor and its receptors in bronchial dypslasia demonstrated by quantitative RT-PCR analysis.	15777969	Lung Cancer
Predicting gene promoter methylation in non-small-cell lung cancer by evaluating sputum and serum.	17406356	Br J Cancer
Premalignant evolution of lung cancer: Gilles F Filley lecture.	15136432	Chest
Prognostic significance of occult tumor cells in the apheresis products of patients with advanced breast cancer receiving high-dose chemotherapy and autologous hematopoietic progenitor cell support.	15148495	Biol Blood Marrow Transplant
Promoter characterization of Semaphorin SEMA3F, a tumor suppressor gene.	16005989	Biochim Biophys Acta
Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort.	16540689	Cancer Res
Proteomic patterns of preinvasive bronchial lesions.	16179643	Am J Respir Crit Care Med
Pulmonary prostacyclin synthase overexpression chemoprevents tobacco smoke lung carcinogenesis in mice.	15313935	Cancer Res
RAGE in lung tumors.	17200506	Am J Respir Crit Care Med
Recent developments in biomarkers for the early detection of lung cancer: perspectives based on publications 2003 to present.	15220746	Curr Opin Pulm Med
Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines.	16424029	Cancer Res
Spectral karyotyping detects chromosome damage in bronchial cells of smokers and patients with cancer.	17600274	Am J Respir Crit Care Med
Sputum cytological atypia as a predictor of incident lung cancer in a cohort of heavy smokers with airflow obstruction.	14578133	Cancer Epidemiol Biomarkers Prev
The bronchioloalveolar carcinoma and peripheral adenocarcinoma spectrum of diseases.	17409882	J Thorac Oncol

Interests

Lung Cancer Detection

The Colorado Biomarkers Discovery Laboratory uses microarray technology to detect abnormal patterns of gene expression in lung cancers to identify candidate biomarkers. These are then tested using amplification methods that permit the identification and quantification of aberrent signals in mixtures of tumor and benign cell. At the present time we are focusing on Cancer/Testis genes because of the near complete absence from all somatic human tissue and their high level of expression in cancers.

Lung premalignancy and carcinogenesis

Central cancer is presumed result from a series of stepwise changes in the bronchial epithelium. Better definition of the molecular configuration of these lesion may permit identification of a patient population that could benefit from screening and chemoprevention. We have utilize samples from a 4000 person cohort of smokers to evaluate methylation of tumor supressor genes (Dr Steve Belinsky), SKY FISH and other cytogenetic abnormalities and abnormal gene expression profiles to identify aberrently expressed genes to construct a profile that may predict for the future development of lung cancer. To date a panel of methylation has been developed that has promise for the prediction of lung cancer before over malignancy occurs. SKY FISH may also be predictive. Finally, a profile of premalignant is being developed. These molecular changes are being compared to the current morphological gold standard to develop molecular tests that may supplement and, in some instances, replace morphological biomarkers.

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Site

University of Colorado Health Science Center

Degree(s)

M.D.

Email

wilbur.franklin@ucdenver.edu

Fax

303-724-3096

Person ID

1081

EDRN Title

Associate Member

Note

To update contact information, please visit the Data Management and Coordinating Center .