Lynch, Henry

Open Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
Biomarkers in Familial Multiple Myeloma	Leading	0	0
Early Detection Research Network Registry for Hereditary Cancer	Coordinating	0	0
EDRN Longitudinal Serum Biorepository	Coordinating	0	0
Hereditary Cancer Institute family study specimen bank	Coordinating	0	0
HNPCC colon cancer-associated SELDI mass spectrometry protein profiles in serum	Leading	0	0
Light Scattering Spectroscopy for the Detection of Colorectal Neoplasia	Coordinating	0	0
Methylation tumor markers in HNPCC	Coordinating	0	0
MMR protein expression in HNPCC	Coordinating	0	0
Novel Surveillance Strategies For Hereditary Nonpolyposis Colon Cancer Family Members	Coordinating	0	0
Prognostic Markers in Lynch Syndrome Colorectal Cancers	Coordinating	0	0
Screen Detection of Mismatch Repair Deficient Colorectal Neoplasias Using a Stool Based DNA Analysis	Leading	0	0

Closed Protocols

Protocol Name	Investigatory Role	Biomarkers
EDRN Resource Network Exchange	Involved	0
Mutational load distribution analysis (MLDA) in pancreatic cancer	Leading	1
Ovarian Cancer Screening Pilot Trial In High Risk Women	Leading	0
Protein profiling for detection of high risk breast cancer	Involved	0
Proteomic Profiling of Serum and Other Body Fluids for the Early Detection of Colon Cancers	Involved	0

Publications

Publication Name	PubMed ID	Journal
[Hereditary diffuse gastric cancer (HDGC): presentation of a family with a new mutation of the CDH1 gene].	17955726	Acta Gastroenterol Latinoam
A founder mutation of the MSH2 gene and hereditary nonpolyposis colorectal cancer in the United States.	14871915	JAMA
Accurate classification of MLH1/MSH2 missense variants with multivariate analysis of protein polymorphisms-mismatch repair (MAPP-MMR).	18383312	Hum Mutat
Advances in counselling and surveillance of patients at risk for pancreatic cancer.	17872573	Gut
Age at first birth and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.	17245541	Breast Cancer Res Treat
American founder mutation for Lynch syndrome. Prevalence estimates and implications.	16353207	Cancer
BRCA1 and pancreatic cancer: pedigree findings and their causal relationships.	15796958	Cancer Genet Cytogenet
Cancer in Jews: introduction and overview.	15516840	Fam Cancer
Cancer risk in mismatch repair gene mutation carriers.	14574017	Fam Cancer
Carrier risk status changes resulting from mutation testing in hereditary non-polyposis colorectal cancer and hereditary breast-ovarian cancer.	12920070	J Med Genet
Challenging colonic polyposis pedigrees: differential diagnosis, surveillance, and management concerns.	14734220	Cancer Genet Cytogenet
Challenging pancreatic cancer-prone pedigrees: a nosologic dilemma.	12492191	Am J Gastroenterol
Colon cancer screening practices following genetic testing for hereditary nonpolyposis colon cancer (HNPCC) mutations.	15451763	Arch Intern Med
Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.	18355772	Am J Hum Genet
Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia.	17540169	Cell
Familial adenomatous polyposis and extracolonic cancer.	11713930	Dig Dis Sci
Familial adenomatous polyposis in children younger than age ten years: a multidisciplinary clinic experience.	18157572	Dis Colon Rectum
Familial multiple myeloma: a family study and review of the literature.	11584064	J Natl Cancer Inst
Familial pancreatic carcinoma in Jews.	15516847	Fam Cancer
Familial sarcoma: challenging pedigrees.	14584079	Cancer
Family with acute myelocytic leukemia, breast, ovarian, and gastrointestinal cancer.	12377407	Cancer Genet Cytogenet
Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer.	17545690	JAMA
Frequency of the CHEK2 1100delC mutation among women with breast cancer: an international study.	18381420	Cancer Res
Gastric cancer: new genetic developments.	15895459	J Surg Oncol
Germline RAP80 mutations and susceptibility to breast cancer.	18306035	Breast Cancer Res Treat
Hereditary breast cancer: part I. Diagnosing hereditary breast cancer syndromes.	18086272	Breast J
Hereditary breast cancer: part II. Management of hereditary breast cancer: implications of molecular genetics and pathology.	18086271	Breast J
Hereditary breast-ovarian cancer at the bedside: role of the medical oncologist.	12586815	J Clin Oncol
Hereditary cancer syndrome diagnosis: molecular genetic clues and cancer control.	17381417	Future Oncol
Hereditary cancer: family history, diagnosis, molecular genetics, ecogenetics, and management strategies.	11900873	Biochimie
Hereditary chronic lymphocytic leukemia: an extended family study and literature review.	12407690	Am J Med Genet
Hereditary colorectal cancer.	12621137	N Engl J Med
Hereditary diffuse gastric cancer: diagnosis, genetic counseling, and prophylactic total gastrectomy.	18442100	Cancer
Hereditary nonpolyposis colorectal cancer (Lynch Syndrome) in Argentina: report from a referral hospital register.	17846840	Dis Colon Rectum
Hereditary nonpolyposis colorectal carcinoma (HNPCC) and HNPCC-like families: Problems in diagnosis, surveillance, and management.	14692024	Cancer
History and molecular genetics of Lynch syndrome in family G: a century later.	16264161	JAMA
Immunology and the Lynch syndrome.	18395102	Gastroenterology
Inflammatory bowel disease in Ashkenazi Jews: implications for familial colorectal cancer.	15516846	Fam Cancer
Inherited predisposition to cancer: a historical overview.	15264268	Am J Med Genet C Semin Med Genet
International variation in rates of uptake of preventive options in BRCA1 and BRCA2 mutation carriers.	18196574	Int J Cancer
Intra-abdominal carcinomatosis after prophylactic oophorectomy in women of hereditary breast ovarian cancer syndrome kindreds associated with BRCA1 and BRCA2 mutations.	15863145	Gynecol Oncol
Loss of surface and cyst epithelial basement membranes and preneoplastic morphologic changes in prophylactic oophorectomies.	14669280	Cancer
Lynch syndrome and the role of the registered nurse: commentary on "hereditary nonpolyposis colorectal cancer (Lynch syndrome): molecular pathogenesis and clinical approaches ti diagnosis and management for nurses".	18077772	Biol Res Nurs
Lynch syndrome: genetics, natural history, genetic counseling, and prevention.	11060321	J Clin Oncol
Lynch syndrome: history and current status.	15528784	Dis Markers
Multiple primary cancer, including transitional cell carcinoma of the upper uroepithelial tract in a multigeneration HNPCC family: molecular genetic, diagnostic, and management implications.	12650804	Am J Gastroenterol
Mutational load distribution analysis yields metrics reflecting genetic instability during pancreatic carcinogenesis.	18337498	Proc Natl Acad Sci U S A
Origins and prevalence of the American Founder Mutation of MSH2.	18381419	Cancer Res
Patient responses to the disclosure of BRCA mutation tests in hereditary breast-ovarian cancer families.	16527602	Cancer Genet Cytogenet
Phenotypic and genotypic heterogeneity in the Lynch syndrome: diagnostic, surveillance and management implications.	16479259	Eur J Hum Genet
Phenotypic heterogeneity in multiple myeloma families.	15681516	J Clin Oncol
Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families: the familial atypical mole melanoma-pancreatic carcinoma syndrome.	11815963	Cancer
Predictors of contralateral prophylactic mastectomy in women with a BRCA1 or BRCA2 mutation: the Hereditary Breast Cancer Clinical Study Group.	18195327	J Clin Oncol
RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies.	17999359	Am J Hum Genet
Risk-reducing salpingo-oophorectomy for the prevention of BRCA1- and BRCA2-associated breast and gynecologic cancer: a multicenter, prospective study.	18268356	J Clin Oncol
Screening adherence in BRCA1/2 families is associated with primary physicians' behavior.	14755459	Am J Med Genet A
The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome.	18398828	Int J Cancer
Three new mutations in hereditary nonpolyposis colorectal cancer (Lynch syndrome II) in Uruguay.	12660027	Cancer Genet Cytogenet
Toward a consensus in molecular diagnosis of hereditary nonpolyposis colorectal cancer (Lynch syndrome).	17312298	J Natl Cancer Inst
Tumor-infiltrating lymphocytes are a marker for microsatellite instability in colorectal carcinoma.	11413533	Cancer
Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy.	18458673	Lab Invest
Who should be sent for genetic testing in hereditary colorectal cancer syndromes?	17687158	J Clin Oncol

Interests

No interests found at the present moment.

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Site: Creighton University
Email: No email set
Person ID: 5170
EDRN Title: EDRN Associate Member
Note: To update contact information, please visit the Data Management and Coordinating Center .