7:00 am-8:00 am

Registration/Sign-in

N/A

N/A

8:00 am-8:05 am

Call to Order and Approval of Minutes

Karen Anderson, MD, PhD
Arizona State University

N/A

8:05 am-8:20 am

Welcome Remarks

Robert Bresalier, MD and
Ernest Hawk, MD, Chief, Division of Cancer Prevention
The University of Texas MD Anderson Cancer Center

01

8:20 am-8:25 am

State of the EDRN

Sudhir Srivastava, PhD, MPH, Senior Scientific Officer & Chief, Cancer Biomarkers Branch
National Cancer Institute

02

8:25 am-9:05 am

9:05 am-9:15 am Q&A

Keynote Address: The Role and Responsibilities of Cancer Prevention in a Comprehensive Cancer Center

Ernest Hawk, MD, Chief, Division of Cancer Prevention, The University of Texas MD Anderson Cancer Center

03

9:15 am-9:30 am

Break and Networking

N/A

N/A

9:30 am-12:00 pm

Discussion: Challenges and Decision Points in Biomarker Discovery and Validation

Scientific Intent: Identify high-impact decision points determining whether a biomarker program should proceed, pivot, or stop.

Desired Outputs: Defined go/no-go criteria, minimum evidence standards, and mitigation strategies.

Moderator(s)

Cecilia Yeung, MD, Fred Hutchinson Cancer Center

Guillermo Marquez, PhD, National Cancer Institute

15 minute break during this session

04

1:00 pm-3:00 pm

Lunch

N/A

N/A

1:00 pm-3:00 pm

EDRN Executive Committee Meeting

N/A

N/A

3:15 pm-6:15 pm

EDRN Collaborative Group Meetings

See Below for Room Assignments

See Separate Agendas

3:15 pm-6:15 pm

Breast & Gynecological Cancers

Room CPB8 Rms 1-2 Duncan Building

Agenda

3:15 pm-6:15 pm

Gastrointestinal Cancers

Room CPB8 Rms 3-4 Duncan Building

Agenda

3:15 pm-6:15 pm

Lung and Upper Aerodigestive Cancers

Onstead Auditorium S3.8012

Agenda

3:15 pm-6:15 pm

Genitourinary and Prostate Cancers

Room CPB8 Rms 5-6

Agenda

7:00 am-8:00 am

Registration and Sign-In

N/A

N/A

8:00 am-8:40 am

8:40 am-8:50 am Q&A

Keynote Address: Cancer without disease: combining the concept of healthy living and aging with strategies to diagnose and prevent malignant disease of cancer.

Raghu Kalluri, MD PhD
The University of Texas MD Anderson Cancer Center

06

8:50 am-10:10 am

Data Science, Digital Infrastructure, and Biomarkers

Scientific Intent: Ensure EDRN data assets are discoverable, reusable, and decision-relevant.

Desired Outputs: Prioritized roadmap for dashboards, metadata standards, and public datasets.

Moderator(s)

Jennifer Beane, PhD, Boston University

Nick Hodges, PhD, National Cancer Institute

07

10:10 am-10:40 am

Break and Networking

N/A

N/A

10:40 am-12:00 pm

Funding Environment, Rigor, and Reproducibility

Scientific Intent: Translate funder expectations into concrete lab and network-level practices.

Desired Outputs: Rigor & Reproducibility checklist and reporting templates.

Moderator(s)

Jennifer Beane, PhD, Boston University

Nick Hodges, PhD, National Cancer Institute

08

12:00 pm-2:00 pm

Lunch and Networking (On Your Own)

N/A

N/A

2:00 pm-3:35 pm

Collaborative Group Updates

See Below

N/A

2:00 pm-2:15 pm

2:15 pm-2:20 pm Q&A

Breast and Gynecological Cancers

Co-chair: Savannah Partridge, PhD, Fred Hutchinson Cancer Center

Co-chair: Abhijit Patel, MD, PhD, Yale School of Medicine

09

2:20 pm-2:35 pm

2:35 pm-2:40 pm Q&A

Prostate and Urologic Cancers

Co-chair: Jeff Tosoian, MD, Vanderbilt University Medical Center

10

2:40 pm-2:55 pm

2:55 pm-3:00 pm Q&A

Gastrointestinal and Associated Cancers

Co-chair: Robert Bresalier, MD, The University of Texas MD. Anderson Cancer Center

Co-chair: Cecilia Yeung, MD, Fred Hutchinson Cancer Center

11

3:00 pm-3:15 pm

Break and Networking

N/A

N/A

3:15 pm-3:30 pm

3:30pm-3:35pm Q&A

Lung

Co-chair: Marc Lenburg, PhD, Boston University

Co-chair: Eric Grogan, MD, Vanderbilt University Medical Center

12

3:35 pm-3:50 pm

3:50 pm-3:55 pm Q&A

AHEAD Steering Committee Summary

Sara Pai, PhD Yale University

Yu Leo Lei, DDS, PhD - The University of Texas MD Anderson Cancer Center

13

3:55 pm-4:10 pm

4:10 pm-4:15 Q&A

Update on EDRN Liver Clinical Utility Trial (TRACER)

Moderator(s)

• Ziding Feng, PhD, Fred Hutchinson Cancer Center
• Steven Skates, PhD, Massachusetts General Hospital
• Wendy Wang, PhD, National Cancer Institute

14

14a

14b

4:15 pm-4:30 pm

Break and Networking

N/A

N/A

4:30 pm-5:30 pm

Panel Discussion – Publishing Negative and Null Results:

Scientific Intent: Preserve well-designed null findings to improve decision quality.

Desired Outputs: Agreement on criteria and dissemination pathways for negative results.

Moderator(s)

• Ziding Feng, PhD, Fred Hutchinson Cancer Center
• Steven Skates, PhD, Massachusetts General Hospital
• Wendy Wang, PhD, National Cancer Institute

15

7:00 am-8:00 am

Registration & Sign-In

N/A

N/A

8:00 am-8:40 am

8:40 am-8:50 am Q&A

Keynote Address: Blood-based metabolic signatures of microbial dysbiosis and pancreas exocrine dysfunction for risk assessment of pancreatic cancer

Johannes Fahrmann, PhD The University of Texas MD Anderson Cancer Center

16

8:50 am-9:00 am

Break and Networking

N/A

N/A

9:00 am-11:30 am

EDRN Leadership Summit – Fireside Chat

Scientific Intent: Convert discussions into commitments with timelines.

Desired Outputs: 90-day action plan and 12-month metric dashboard.

Moderator(s)

Karen Anderson, MD, PhD Arizona State University/Mayo Clinic

Invited presenter:

Larry Norton, MD, Memorial Sloan Kettering Cancer Center

17

11:30 am

Adjourn EDRN Steering Committee Meeting

N/A

N/A